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Inherent Macrophage Defects in Mice

  • Chapter
Book cover Immunologic Defects in Laboratory Animals 1

Abstract

Macrophages represent a highly diverse population of “phagocytic monocytes,” capable of effecting a number of important biological functions. The ubiquitous nature of macrophages as a network of circulating and fixed scavengers within the tissues, combined with their complex phagocytic and detoxifying abilities, subserve their role as the primary host surveillance system. One major function of macrophages is to protect the host from harmful infectious agents, particularly in the early phases of infection, prior to the establishment of a specific immune response. To this end, highly differentiated or “activated” macrophages (Mackaness, 1969) are capable of killing intracellular parasites and tumor cells. In addition to the ability to deal directly with invading microorganisms, the macrophage has been shown to be the source of a number of “monokines” (substances synthesized by macrophages) such as lymphocyte-activating factor, prostaglandins, and certain complement components, each of which modulates the immune response. Moreover, macrophages have clearly been implicated as an essential accessory cell in the establishment of antigen-specific immune responses, and in some cases may act to suppress both humoral and cellular immune functions.

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Authors and Affiliations

  1. Laboratory of Microbiology and Immunology, National Institute of Dental Reserach, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Stefanie N. Vogel & Anita Corman Weinblatt

  2. Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

    David L. Rosenstreich

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  1. University of California School of Medicine, Davis, California, USA

    M. Eric Gershwin

  2. Food and Drug Administration, Bethesda, Maryland, USA

    Bruce Merchant

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Vogel, S.N., Weinblatt, A.C., Rosenstreich, D.L. (1981). Inherent Macrophage Defects in Mice. In: Gershwin, M.E., Merchant, B. (eds) Immunologic Defects in Laboratory Animals 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0325-2_15

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  • DOI: https://doi.org/10.1007/978-1-4757-0325-2_15

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4757-0325-2

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