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Drugs and the Colon

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Colon

Part of the book series: Topics in Gastroenterology ((TGEN))

Abstract

It is not our intention to review drug effects in the colon, which was done extensively and profoundly by Forth and Rummel1 and Powell.2 Our contribution will present studies of drug effects on physiological absorption and secretion processes obtained in the intact human colon and based on results of intestinal perfusion studies of the whole colon and measurements of transepithelial electrical potential difference (PD) in the rectosigmoid colon. These are at present the practiced and—regarding perfusion studies—most accurate techniques in the hands of clinicians to directly study drug effects on a local dose-response scale in the intact human colon. Since these methods are relatively new and their use practically limited to clinical research, no extensive data on this topic are yet available.

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Authors and Affiliations

  1. I. Medizinische Klinik und Poliklinik, Universität Mainz, Mainz, Federal Republic of Germany

    R. Wanitschke & K. Ewe

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  1. R. Wanitschke
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  2. K. Ewe
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Editors and Affiliations

  1. School of Medicine, Buenos Aires University, Buenos Aires, Argentina

    Luis Bustos-Fernández M.D.

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© 1983 Plenum Publishing Corporation

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Wanitschke, R., Ewe, K. (1983). Drugs and the Colon. In: Bustos-Fernández, L. (eds) Colon. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0307-8_14

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  • DOI: https://doi.org/10.1007/978-1-4757-0307-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0309-2

  • Online ISBN: 978-1-4757-0307-8

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