Abstract
The constant supply of blood cells required to maintain a normal steady state by replacing the cells lost through senescence is of the order of 4 × 10″ cells per day in a normal human adult, and is even larger in response to haemopoietic stress like blood loss or infection. All blood cells are derived from stem cells in the bone marrow tissue in the adult. The stem cells are characterized by a) their capacity to reconstitute the haemopoietic system of individuals who had received a potentially lethal dose of irradiation, b) their capacity of self-renewal by which they can regenerate their own population after serious and repeated depletion caused by cytotoxic injury, and c) their multipotentiality, i.e. they give rise to all the myeloid and lymphoid cell types.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allen, T. and Dexter, T.M., (1983. Long term bone marrow culture: an ultrastructural review, Scanning electron microsc. 4, 1951.
Chang, J., Coutinho, L., Morgenstern, G., Scarffe, J.H., Deakin, D., Harrison, C., Testa, N.G. and Dexter, T.M. 1986 Marrow from AML in relapse and grown in long term culture can be used to reconstitute the haemopoietic system by autologous bone marrow transplantation, The Lancet 1, 293.
Coutinho, L.H., Testa, N.G., Chang, J., Morgenstern, G., Harrison, C., Dexter, T.M. 1989 The use of cultured bone marrow cells in autologous transplantation, Leukemia, in press.
Dexter, T.M. (1982) Stroma cell associated haemopoiesis. J. Cell Physiol., suppl. 1, 87.
Dexter, T.M. and Spooncer, E. (1978. Loss of immunoreactivity in long term bone marrow culture, Nature, 275: 135.
Eliason, J.F., (1984. Long term production of hemopoietic progenitors in cultures containing low levels of serum, Exp. Hematol. 12: 559.
Fausser, A.A. and Messner, H.A. (1979. Identification of megakaryocytes, macrophages and eosinophils in colonies of human bone marrow containing neutrophilic granulocytes and erythroblasts, Blood 53, 1023.
Gianni, A.M., Bregni, M., Stern, A.C., Siena, S., Tarella, C., Pileri, A and Bonadona, G., 1989. Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation, The Lancet ii, 580.
Goldvasser, E., Beru, N. and Smith, D. 1989. Erythropoietin in: Cellular andmolecular biology of colony stimulating factors, Dexter, T.M., Garland, J. and Testa, N.G. eds. M. Dekker, New York p. 257.
Gordon, M.V., Riley, G.P., Watt, S.M., Greaves, M.F. (1987. Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment, Nature 326, 403.
Gough, N.M. and Nicola, N. 1989. Granulocyte-macrophage colony-stimulating factor in: Cellular and molecular biology of colony stimulating factors, Dexter, T.M., Garland, J. and Testa, N.G. eds. M. Dekker, NY p.111.
Harrison, D. and Astle, C.H. (1982. Loss of stem cell repopulating ability on transplantation; Effects of donor age, cell number and transplantation procedure, J. Exp. Med. 156, 1767.
Heyworth, CM., Ponting I.L.O. and Dexter T.M. (1988. The response of haemopoietic cells to growth factors: developmental implication of synergistic interactions, J. Cell Sci. 91, 239.
Humphries, R.K., Evans, A.C. and Eaves, C.J. 1981. Self-renewal of hemopoietic stem cells during mixed colony formation in vitro, Proc. Natl. Acad. Sci. USA, 3629.
Lord, B.I. and Testa, N.G. 1988 The hemopoietic system: structure and regulation. in: Hematopoiesis, long term effects of chemotherapy and radiation. Testa, N.G. and Gale, R.P. eds. M. Dekker, New York p.1.
Metcalf, D. 1977 Haemopoietic colonies. Springer Verlag, Berlin.
Metcalf, D. 1984. The haemopoietic colony stimulating factors. Elsevier. Amsterdam.
Metcalf, D. 1988. The molecular control of blood cells. Harvard University Press, Cambridge, Mass.
Metcalf, D., Johnson, G.R., Burges, A.W. (1979 Colony formation in agar by multipotential hemopoietic cells J. Cell Physiol. 98, 401.
Nicola, N. 1989 Granulocyte colony stimulating factor in cellular and molecular biology of colony stimulating factors. Dexter, T.M., Garland, J. and Testa, N.G., eds. M. Dekker, New York, p.77.
Roberts, R.A., Gallaher, J.T., Spooncer, E., Allen, T.D., Bloomfield, F. and Dexter, T.M. 1988. Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis. Nature 332, 376.
Sanderson, C.J. 1989 Eosinophil differentiation factor (Interleukin 5) in: Cellular and Molecular biology of colony stimulating factors Dexter, T.M., Garland, J. and Testa, N.G. eds. M. Dekker, New York p. 231.
Spivak, J.L., Smith, R.R. and Ihle, J.N. (1985. Interleukin 3 promotes the in vitro proliferation of murine pluripotent stem cells. J. Clin. Invest. 76: 1613.
Testa, N.G. 1985. Clonal assays for haemopoietic and lymphoid cells in vitro. In: Cell clones: manual of mammalian cell techniques. Potten, C.S., Hendry, J.H. eds.
Testa, N.G., Hendry, J. and Molineux, G. (1985. Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy. Anticancer Res. 5, 101.
Testa, N.G., Coutinho, L., Chang J., Morgenstern, G., Scarffe, J.H. and Dexter, T.M. (1987. The use of cultured bone marrow cells for autologous transplantation in patients with acute myeloblastic leukaemia. Haematol. Blood Trans. 31, 75.
Testa, N.G. and Dexter, T.M. 1989. Haemopoietic growth factors: their role in cell development and their clinical use, Cytotechnology, in press.
Weiss, L., (1976. The hematopoietic environment of the bone marrow: an ultrastructural study of the stroma in rats. Anat. Rec. 186, 161.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Testa, N.G., Dexter, T.M., Allen, T.D. (1991). Regulation of Haemopoietic Cell Development. In: Wilson, G., Davis, S.S., Illum, L., Zweibaum, A. (eds) Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport. NATO ASI Series, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0286-6_24
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0286-6_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0288-0
Online ISBN: 978-1-4757-0286-6
eBook Packages: Springer Book Archive