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Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport pp 175–189Cite as

Transport of Drugs Across the Blood-Brain Barrier: In Vitro and in Vivo Strategies

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Part of the book series: NATO ASI Series ((NSSA,volume 218))

Abstract

The transport rate across the BBB is an essential kinetic parameter for drugs acting on the central nervous system, because it determines the time to onset and the intensity of drug action.1,2 For the study of BBB-passage in vivo, various models have been described, however most techniques require the use of many experimental animals and offer only limited information.3–5 Moreover, in the in vivo situation the estimated transport parameters are inevitably influenced by physiological factors which cannot be kept under control during the experiment (e.g. cerebral blood flow, hormone levels, stress levels).6 Therefore comparison of BBB transport parameters obtained in different experimental settings is hazardous.

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Author information

Authors and Affiliations

  1. Division of Pharmacology, Center for Bio-Pharmaceutical Sciences, University of Leiden, Leiden, The Netherlands

    Joost B. M. M. van Bree, Albertus G. de Boer, Meindert Danhof & Douwe D. Breimer

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  1. Joost B. M. M. van Bree
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  2. Albertus G. de Boer
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  3. Meindert Danhof
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  4. Douwe D. Breimer
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Editors and Affiliations

  1. SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA

    Glynn Wilson

  2. University of Nottingham, Nottingham, UK

    S. S. Davis  & L. Illum  & 

  3. INSERM, Paris, France

    Alain Zweibaum

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© 1991 Plenum Press, New York

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van Bree, J.B.M.M., de Boer, A.G., Danhof, M., Breimer, D.D. (1991). Transport of Drugs Across the Blood-Brain Barrier: In Vitro and in Vivo Strategies. In: Wilson, G., Davis, S.S., Illum, L., Zweibaum, A. (eds) Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport. NATO ASI Series, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0286-6_14

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  • DOI: https://doi.org/10.1007/978-1-4757-0286-6_14

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4757-0286-6

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