Abstract
Following the institution of lithium therapy in the management of manic states, observers noted that leukocytosis and neutrophilia frequently occurred (Risetto and Gassano, 1952; Mayfield and Brown, 1966; O’Connell, 1970; Murphy and Goodwin, 1971; Shopsin and Friedman, 1971). In 1973, Tisman et al. postulated that the neutrophilia was due to an increase in the total blood granulocyte pool and also demonstrated augmentation of granulocyte proliferation in vitro (Tisman et al., 1973). In 1975, it was demonstrated that lithium enhanced colony stimulating activity (CSA) production in mice (Harker et al., 1975), and humans (Joyce and Chervenick, 1975), suggesting that this CSA alteration had a mechanistic role in vivo. In the present study, we have examined the action of lithium upon murine granulocytopoiesis in vivo and in vitro in order to: 1) further define the action of lithium upon CSA production by lung, adherent peritoneal cells, and marrow; 2) to examine the direct effect of lithium upon the proliferation of colony forming cells (CFC) or their progeny; and 3) to test the hypothesis that lithium stimulation of CSA production is due to modulation of cellular cyclic AMP (cAMP) levels.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bradley, T.R. and Metcalf, D. 1966, The growth of mouse bone marrow cells in vitro, Aust. J. Exp. Biol. Med. Sci. 44:287.
Chervenick, P.A., Boggs, D.R., Marsh, J.C., Cartwright, G.E. and Wintrobe, M.M., 1973, Quantitative studies of blood and bone marrow neutrophils in normal mice, Amer. Jour. Phys. 215:353.
Fehir, K.M. and Rossof, A.H., 1977, Lithium carbonate stimulation of marrow colony forming units and peripheral granulocytes in a canine model, Blood 50:145 (Supplement 1).
Gupta, R.C., Robinson, W.A. and Kurnick, J.E., 1976, Felty’s syndrome: effect of lithium on granulopoiesis, Am. J. Med. 61:29.
Hammond, W.P. and Dale, D.C., 1979, Canine cyclic hematopoiesis: Treatment with lithium, Clin. Res. 27:461A.
Harker, G.W., Rothstein, G., Clarkson, D.W. and Athens, J.W., 1975, Stimulation of neutrophil production by lithium, Clin. Res. 23:103A.
Harker, W.G., Rothstein, G., Clarkson, J., Athens, J.W., and MacFarlane, J.L., 1977, Enhancement of colony-stimulating activity production by lithium, Blood 49:263.
Iscove, N.N., 1972, Technique for culture of human CFU-c, in “In vitro culture of hemopoietic cells,” (Van Bekkum, D.W. and Dicke, K.A., eds.), Rijswijk Radiobiol. Inst. TNO.
Joyce, R.A. and Chervenick, P.A., 1975, Effect of lihtium on the release of colony-stimulating activity (CSA) from blood leukocytes, Proc. Amer. Soc. Hematol. 18:126.
Joyce, R.A. and Chervenick, P.A., 1979, Lithium effect on granulopoiesis following vinblastine, Clin. Res. 27:388A.
Lee, R.V., Jampol, L.M. and Brown, W.V., 1971, Nephrogenic diabetes insipidus and lithium intoxication — complications of lithium carbonate therapy, N. Engl. J. Med. 284:93.
Mayfield, D. and Brown, R.G., 1966, The clinical laboratory and electroencephalographc effects of lithium, J. Psychiatr. Res. 4:207.
Murphy, D.L. and Goodwin, F.K., 1971, Leukocytosis during lithium treatment, J. Psych. Res. 127:1559.
O’Connell, R.A., 1970, Leukocytosis during lithium carbonate treatment, Int. J. Pharmacopsychiatry 4:30.
Pluznik, D.H. and Sachs, L., 1965, The cloning of normal mast cells in tissue culture, J. Cell Comp. Physiol. 66:319.
Risetto, G. and Gassano, G., 1952, Variazioni del sanque perifico nella intossicazione sperimentale da sali di litio, Riv. Patol. Clin. Sper. 7:202.
Rothstein, G., Clarkson, D.R., Larsen, W., Grosser, B.I., and Athens, J.W., 1978, Effect of lithium on neutrophil mass and production, New Engl. J. Med. 298:178.
Sheridan, J.W. and Metcalf, D., 1974, CSF production and release following endotoxin, in “Hemopoiesis in Culture, 2nd International Workshop,” (Robinson, W.A., ed.), Washington, D.C., NIH 74-205.
Shopsin, B. and Friedman, R., 1971, Lithium and leukocytosis, Clin. Pharmacol. Ther. 12:923.
Singer, I. and Rotenberg, D., 1973, Mechanisms of lithium action, New Eng. J. Med. 289:254.
Stein, R.S., Beaman, C., Ali, M.Y., Hansen, R., Jenkins, D.D. and Jum’ean, H.G., 1977, Lithium carbonate attenuation of chemotherapy-induced neutropenia, New Engl. J. Med. 297:430.
Tisman, G., Herbert, V., and Rosenblatt, S., 1973, Evidence that lithium induces human granulocyte proliferation: Elevated serum vitamin B12 binding capacity in vivo and granulocyte colony proliferation in vitro, Br. J. Haematol. 24:767.
Zurier, R.B., Weissmann, G., Hoffstein, S., Kammerman, S., and Tai, H.H., 1974, Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function, J. Clin. Invest. 53:297.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Rothstein, G., Oshita, A.K., Harker, W.G., Lonngi, G., Christensen, R.D. (1980). The Effect of Lithium Upon Granulocyte Production in vitro and in vivo in the Mouse. In: Rossof, A.H., Robinson, W.A. (eds) Lithium Effects on Granulopoiesis and Immune Function. Advances in Experimental Medicine and Biology, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0259-0_5
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0259-0_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0261-3
Online ISBN: 978-1-4757-0259-0
eBook Packages: Springer Book Archive