Abstract
Lithium was observed to increase the number of peripheral neutro-phils in hematologically normal individuals (Shopsin et al., 1971; Bille et al., 1975) and in several primary neutropenic conditions (Tisman and Show-Jen, 1977; Barrett, et al., 1977). When this effect is analysed in people receiving lithium for psychiatric reasons, it appeared to involve predominantly the myeloid cell line, though platelet counts were also increased (Bille et al., 1975). Lithium apparently causes increased neutrophil production by increasing colony stimulating activity (Turner et al., 1978).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barrett, A.J., Hugh-Jones, K., Newton, K. and Watson, J.G., 1977, Lithium therapy in aplastic anemia, The Lancet 2:202.
Bille, P.E., Jensen, M.K., Jensen, J.P. and Poulsen, J.C., 1975, Studies on the haematologic and cytogenetic effect of lithium, Acta Med. Scand. 198:281.
Lozzio, C.B. and Lozzio, B.B., 1975, Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome, Blood 45:321.
Malloy, N.L., Zauber, N.P., Chervenick, P., 1978, The effect of lithium on blood and marrow neutrophils, Blood 52:228, (Supplement 1).
Rosenstock, J.G., 1979, Unpublished observations.
Rosenthal, S., Canellos, G.P., Whang-Peng, J. and Gralnick, H.R., 1977, Blast crisis of chronic granulocytic leukemia, Am. J. Med. 63:542.
Shopsin, B., Friedmann, R. and Gershon, S., 1971, Lithium and leukocytosis, Clin. Pharmacol. Ther. 12:923.
Tisman, G. and Show-Jen, G.W., 1977, Lithium-induced granulocytosis, The Lancet 2:251.
Turner, A.R. and Allalunis, M.J., 1978, Mononuclear cell production of colony stimulating activity in humans taking oral lithium, Blood 52:234, (Supplement 1).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Rosenstock, J., Archer, J., Pequignot, E. (1980). Effect of Lithium on Acute Myelocytic Leukemia Cells in Tissue Culture — a Preliminary Study. In: Rossof, A.H., Robinson, W.A. (eds) Lithium Effects on Granulopoiesis and Immune Function. Advances in Experimental Medicine and Biology, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0259-0_31
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0259-0_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0261-3
Online ISBN: 978-1-4757-0259-0
eBook Packages: Springer Book Archive