Abstract
The ability of lithium salts to stimulate granulopoiesis in hematologically normal subjects with psychiatric disorders (Shopsin et al., 1971) encourages attempts to use lithium to stimulate granulopoiesis in patients with neutropenia. We have studied the in vivo and in vitro effects of lithium salts in aplastic anemia and congenital neutropenia in order to establish the mode of action of lithium and to evaluate its therapeutic role in neutropenic disorders. This paper summarizes clinical experience with lithium in two European centers. The hematological effects of treatment are defined. In addition, in several patients bone marrow culture studies were carried out in order to develop in vitro tests that could predict clinical response to lithium. Ten patients with hypoplastic anemia were seen and treated at the Westminster Hospital and Westminster Children’s Hospital in London and two patients with congenital neutropenia are reported from the Hopital Necker des Enfants Malades, Paris. In addition, seven hematologically normal patients taking lithium for psychiatric disorders were studied at the Westminster Hospital.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ascensao, J., Pahwa, R.N., Kagan, W.A., Hansen, J.A., Moore, M.A.S., and Good, R., 1976, Aplastic anemia: Evidence of an immunological mechanism, Lancet 1:669.
Barrett, A.J., Griscelli, C., Buriot, D., and Faille, A., 1977, Lithium therapy in congenital neutropenia, Lancet 2:1357.
Barrett, A.J., Faille, A., Balitrand, N., Ketels, F., and Najean, Y., 1979, Bone marrow culture in aplastic anemia, J. Clin. Path., in press.
Charron, D., Barrett, A.J., Faille, A., Alby, A., Schmidt, T., and Degos, L., 1977, Lithium in acute myeloid leukemia, Lancet 1:1387.
Dacie, J.V. and Lewis, S.M., 1975, Practical Hematology, 5th Edition, p. 12, Churchill Livingstone, Edinburgh.
Gelfand, E.W., Dosch, H-M., Hastings, D., and Shore, A., 1979, Lithium: A modulator of cyclic AMP-dependent events in lymphocytes, Science 203:367.
Greco, F.A. and Brereton, H., 1977, Lithium carbonate, attentuation of neutropenia from cancer therapy, Oncology 34:153.
Gupta, R.C., Robinson, W.A., and Albrecht, D., 1975, Efficacy of lithium in rheumatoid arthritis with granulocytopenia (Felty’s Syndrome), Ann. Rheum. Dis. 34:156.
Harker, W.G., Rothstein, G., Clarkson, J., Athens, J.W., and MacFarlane, J.L., 1977, Ehancement of colony stimulating activity production by lithium, Blood 49:263.
Hoffman, R., Zanjani, E.D., Vila, J., Zalusky, R., Lutton, J.D., and Wasserman, L.R., 1976, Diamond-Blackfan syndrome: Lymphocyte mediated suppression of erythropoiesis, Science 193:899.
Hoffman, R., Zanjani, E.D., Lutton, J.D., Zalusky, R., and Wasserman, L.R., 1977, Suppression of erythroid colony formation by lymphocytes from patients with aplastic anemia, New Eng. J. Med. 296:10.
Kern, P., Heimpel, H., Heit, W., and Kubanek, B., 1977, Granulocyte progenitor cells in aplastic anemia, Brit. J. Hematol. 35:613.
Pederson, F.K., Hertz, H., Lundsteen, C., Platz, P., and Thomsen, M., 1977, Indication of primary immunodeficiency in Fanconi’s anemia, Acta Ped. Scand. 66:745.
Pike, B.L. and Robinson, W.A., 1970, Human bone marrow colony growth in agar-gel, J. Cell, Physiol. 76:77.
Sharkis, S.J., Ahmed, A., Sensenbrenner, L.L., Jedrezejczak, W.W., Goldstein, A.L., and Sell, K.W., 1978, The regulation of hemopoiesis: Effect of thymosin or thymocytes in a diffusion chamber, in “Experimental Hematology Today, 1978,” p. 17–22, (S.J. Baum and G.D. Ledney, eds.) Springer-Verlag, New York.
Shopsin, B., Friedmann, R., and Gershon, S., 1971, Lithium and leucocytosis, Clin. Pharmacol. Therap. 12:923.
Singer, J.W., Brown, J.E., James, M.C., Doney, K., Warren, R.P., Storb, R., and Thomas, E.D., 1978, Effect of peripheral blood lymphocytes from patients with aplastic anemia on granulocyte colony growth from HLA-matched and mismatched marrows: Effect of transfusion sensitization, Blood 52:37.
Tisman, G., Herbert, V., and Rosenblatt, S., 1973, Evidence that lithium increases human granulocyte proliferation: Elevated serum vitamin B12 binding capacity in vivo, and granulocyte colony proliferation in vitro, Brit. J. Hematol. 24:767.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Barrett, A.J. (1980). Clinical Experience with Lithium in Aplastic Anemia and Congenital Neutropenia. In: Rossof, A.H., Robinson, W.A. (eds) Lithium Effects on Granulopoiesis and Immune Function. Advances in Experimental Medicine and Biology, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0259-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0259-0_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0261-3
Online ISBN: 978-1-4757-0259-0
eBook Packages: Springer Book Archive