Abstract
Coxsackieviruses (CV) are highly prevalent pathogens with the ability to cause fatal diseases in humans. Although Coxsackie B virus (CVB) infections are relatively benign in adults, they can be fatal in children and have been shown to be the cause of meningoencephalitis, myocarditis, hepatitis, and some cases of diabetes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Prabhakar, B. S., Haspel, M. V., McClintock, P. R., and Notkins, A. L., 1982, High frequency of antigenic variants among naturally occurring human Coxsackie B4 virus isolates identified by monoclonal antibodies, Nature (Lond.) 300:374–376.
Prabhakar, B. S., Haspel, M. V., and Notkins, A. L., 1984, Monoclonal antibody techniques applied to viruses, in: Methods in Virology, Vol. VII (C. Maramorosch and H. Koprowski, eds.), pp. 1–18, Academic, New York.
McKearn, T. J., 1980, Cloning of hybridoma cells by limiting dilution in fluid phase. Monoclonal Antibodies: Hybridomas: A New Dimension in Biological Analyses (R. H. Kennett, T. J. McKearn, and K. B. Bechtol, eds.), p. 374, Plenum, New York.
Holland, J. J., 1984, Continuum of change in RNA virus genome, in: Concepts in Viral Pathogenesis (A. L. Notkins and M. B. A. Oldstone, eds.), pp. 137–143, Springer-Verlag, New York.
Holland, J., Spindler, K., Horodyski, F., Grabau, E., Nichol, S., and Vandepol, S., 1982, Rapid evolution of DNA genomes, Science 215:1577–1585.
Prabhakar, B. S., Menegus, M. A., and Notkins, A. L., 1985, Detection of conserved and non-conserved epitopes on Coxsackievirus B4: Frequency of antigenic changes, Virology 146:302–306.
Prabhakar, B. S., McClintock, P. R., Haspel, M. V., Wohlenberg, C., Menegus, M., and Notkins, A. L., 1983, Monoclonal antibodies as probes to study antigenic variations in Coxsackie B viruses, Igiene Mod. 80:1071–1079.
Prabhakar, B. S., and Notkins, A. L., 1984, Antigenic variants of viruses and their relevance to clinical disease, in: Concepts in Viral Pathogenesis (A. L. Notkins and M. B. A. Oldstone, eds.), pp. 158–162, Springer-Verlag, New York.
Webb, S. R., Kearse, K. P., Foulke, C. L., Hartig, P. C., and Prabhakar, B. S., 1986, Neutralization epitope diversity of Coxsackievirus B4 isolates detected by monoclonal antibodies,J. Med. Virol. 20:9–15.
Cao, Y., Schnurr, D. P., and Schmidt, N.J., 1984, Differing cardiotropic and myocar-ditic properties of group B type 4 coxsackievirus strains, Arch. Virol. 80:119–130.
Cao, Y., Schnurr, D. P., and Schmidt, N.J., 1984, Monoclonal antibodies for study of antigenic variation in coxsackievirus type B4: Association of antigenic determinants with myocarditic properties of the virus,J. Gen. Virol. 65:925–932.
Prabhakar, B. S., Srinivasappa, J., and Ray, U. R., 1987, Selection of Coxsackievirus B4 variants with monoclonal antibodies results in attenuation,J. Gen. Virol. 68:865–869.
Beatrice, S. T., Katze, M. G., Zajac, B. A., and Crowell, R. L., 1980, Induction of neutralizing antibodies by the coxsackievirus B3 virion polypeptide, VP2, Virology 104:426–438.
Jerne, N. K., 1974, Towards a network theory of the immune system, Ann. Immunol. Inst. Pasteur 125C:373–389.
Sege, K., and Peterson, P. A., 1978, Use of anti-idiotypic antibodies as cell-surface receptor probes, Proc. Natl. Acad. Sci. USA 75:2443–2447.
Wassermann, N. H., Penn, A. S., Freimuth, P. I., Treptow, N., Wentzel, S., Cleveland, W. L., and Erlanger, B. F., 1982, Anti-idiotypic route to anti-acetylcholine receptor antibodies and experimental myasthenia gravis, Proc. Natl. Acad. Sci. USA 79:4810–4814.
Schreiber, A. B., Couraud, P. O., Andre, C., Vray, B., and Strosberg, A. D., 1980, Anti-alprenolol anti-idiotypic antibodies bind to ß-adrenergic receptors and modulate catecholamine-sensitive adenyl cyclase. Proc. Natl. Acad. Sci. USA 77:7385–7389.
Kennedy, R. C., and Dreesman, G. R., 1985, Immunoglobulin idiotypes: Analysis of viral antigen-antibody systems, Prog. Med. Virol. 31:168–182.
Kennedy, R. C., Melnick, J. L., and Dreesman, G. R., 1984. Antibody to hepatitis B virus induced by injecting antibodies to the idiotype, Science 223:930–931.
Reagan, K.J., Wunner, W. H., Wiktor, T. J., and Koprowski, H., 1983, Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein,J. Virol. 48:660–666.
Ertl, H. C. J., and Finberg, R. W., 1984, Sendai virus-specific T-cell clones: Induction of cytolytic cells by an anti-idiotypic antibody directed against a helper T-cell clone, Proc. Natl. Acad. Sci. USA 81:2850–2854.
Uytdehaag, F. G. C. M., and Osterhaus, A. D. M. E., 1985, Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody,J. Immunol. 134:1225–1229.
Nepom, J. T., Weiner, H. L., Dichter, M. A., Tardieu, M., Spriggs, D. R., Gramm, C. F., Powers, M. L., Fields, B. N., and Green, M. I., 1982, Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells,J. Exp. Med. 155:155–167.
McClintock, P. R., Prabhakar, B. S., and Notkins, A. L., 1986, Anti-idiotypic antibodies against anti-Coxsackievirus B4 monoclonal antibodies, in: Virus Attachment and Entry into Cells (R. L. Crowell and K. Lonberg-Holm, eds.), pp. 36–43, American Society for Microbiology, Washington, D.C.
McClintock, P. R., Prabhakar, B. S., and Notkins, A. L., 1986, Anti-idiotypic antibodies to monoclonal antibodies that neutralize Coxsackievirus B4 do not recognize viral receptors, Virology 150:352–360.
Hogle, J. M., Chow, M., and Filman, D. J., 1985, Three dimensional structure of poliovirus at 2.9, A resolution, Science 229:1358–1365.
Rossmann, M. G., Arnold, E., Erickson, J. W., Frankenberger, E. A., Griffith, J. P., Hecht, H-J., Johnson, J. E., Kamer, G., Luo, M., Mosser, A. G., Rueckert, R. R., Sherry, B., and Vriend, G., 1985, Structure of a human common cold virus and functional relationship to other picornaviruses, Nature (Lond.) 317:145–153.
Saegusa, J., Prabhakar, B. S., Essani, K., McClintock, P. R., Fukuda, Y., Ferrans, V.J., and Notkins, A. L., 1986, Monoclonal antibody to Coxsackievirus B4 reacts with myocardium./. Infect. Dis. 153:372–373.
Srinivasappa, J., Saegusa, J., Prabhakar, B. S., Gentry, M. K., Buchmeier, M. J., Wiktor, T. J., Koprowski, H., Oldstone, M. B. A., and Notins, A. L., 1986, Molecular mimicry: Frequency of reactivity of monoclonal antiviral antibodies with normal tissues,J. Virol. 57:397–401.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Prabhakar, B.S. (1988). Application of Monoclonal Antibodies to the Study of Coxsackieviruses. In: Bendinelli, M., Friedman, H. (eds) Coxsackieviruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0247-7_8
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0247-7_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0249-1
Online ISBN: 978-1-4757-0247-7
eBook Packages: Springer Book Archive