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The Role of Immune Mechanisms in Pathogenesis

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Coxsackieviruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Although most coxsackievirus (CV) infections in humans are mild and frequently asymptomatic, in some individuals more serious manifestations develop, including meningitis, paralysis, encephalitis, type I (insulin-dependent) diabetes mellitus (IDDM), and myocarditis.1–3 Association of particular viral infections with certain diseases usually depends on demonstration of rising antibody titers to the pathogen and a compatible clinical history. In both IDDM and myocarditis, approximately 50% of recently diagnosed patients demonstrate two- to fourfold rises in CV-specific antibodies compared with less than 20% of control patients.2,3 Furthermore, several studies report dramatic increases in new diabetes and myocarditis cases coinciding with known CV epidemics and also demonstrate definite seasonality for these diseases (fall and winter) that correlate remarkably well with the seasonal distribution of Picornavirus infections.2,3 Despite the nearly convincing circumstantial evidence of CV etiology in myocarditis and diabetes, infectious virus is only rarely isolated from patients with active disease.3

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Vermont, Burlington, Vermont, 05405, USA

    Sally Ann Huber

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  1. Sally Ann Huber
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Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1988 Plenum Press, New York

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Huber, S.A. (1988). The Role of Immune Mechanisms in Pathogenesis. In: Bendinelli, M., Friedman, H. (eds) Coxsackieviruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0247-7_7

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  • DOI: https://doi.org/10.1007/978-1-4757-0247-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0249-1

  • Online ISBN: 978-1-4757-0247-7

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