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Coxsackieviruses pp 81–102Cite as

Interactions with the Immune System

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Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

For many years, coxsackieviruses (CV) and other enteroviruses have been considered relatively unsophisticated pathogens. They were believed to produce acute infections only and to induce tissue damage and disease exclusively by causing lysis of infected target cells. This contention was based on consistent observations showing that, provided cells are susceptible to infection, CV dramatically damaged or destroyed them, owing to a rapid and virtually complete virus-mediated shutoff of protein synthesis followed by cell lysis in a few hours. Accordingly, necrotic lesions in target organs, such as central nervous system (CNS), pancreas, liver, and myocardium, were viewed solely as the result of local viral replication and cytopathic effect produced by the infecting CV, while immune responses were considered to play only a protective role.

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Author information

Authors and Affiliations

  1. Institute of Epidemiology, Hygiene and Virology, University of Pisa, I-56100, Pisa, Italy

    Mauro Bendinelli, Pier Giulio Conaldi & Donatella Matteucci

Authors
  1. Mauro Bendinelli
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  2. Pier Giulio Conaldi
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  3. Donatella Matteucci
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Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1988 Plenum Press, New York

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Bendinelli, M., Conaldi, P.G., Matteucci, D. (1988). Interactions with the Immune System. In: Bendinelli, M., Friedman, H. (eds) Coxsackieviruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0247-7_6

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  • DOI: https://doi.org/10.1007/978-1-4757-0247-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0249-1

  • Online ISBN: 978-1-4757-0247-7

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