Abstract
The term diabetes refers to a group of disorders having in common hyperglycemia and an elevated prevalence of serious complications affecting many organ systems. Studies of the natural history and pathogenesis of hyperglycemia have led to a widely accepted classification developed by the National Diabetes Data Group. Among the various diabetic syndromes that are now recognized, insulin-dependent diabetes mellitus (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) account for the great majority of cases, the former being less prevalent. It is now clear that IDDM derives from a deficiency of insulin production due to the loss of pancreatic β-cells, while NIDDM is mostly due to a reduced effect of this hormone on peripheral tissues. Because coxsackieviruses (CV), and in particular the members of group B (CVB), have been implicated only in the etiopathogenesis of IDDM, this discussion refers exclusively to this form of diabetes.
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Toniolo, A., Federico, G., Basolo, F., Onodera, T. (1988). Diabetes Mellitus. In: Bendinelli, M., Friedman, H. (eds) Coxsackieviruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0247-7_20
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