Skip to main content
SpringerLink
Log in

Relationship of Coxsackievirus to Cardiac Autoimmunity

  • Chapter
Coxsackieviruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

For many years, a relationship between viral infection and the development of autoimmunity has been suspected in diseases such as diabetes mellitus,1–3 multiple sclerosis,45 idiopathic thrombocytopenia purpura,6 chronic active hepatitis,7 postmeasles encephalitis,8,9 and myocarditis.10,12 During the past decade, significant strides have been made in developing an understanding of this intricate and involved relationship. Some of the most studied experimental models are encephalomyocarditic virus-induced and coxsackievirus B4 (CVB4)-induced diabetes mellitus in mice, which have been investigated by Notkins and Yoon and colleagues.1,13–15 Their studies have shown that both the genetics of the host and the infectious agent determine the host’s susceptibility to viral infection, the virus-induced pathology, and the development of autoimmune disease. These investigators have also attempted to clarify the relationship of the virus with organ-specific autoimmunity by hybridizing antibody-forming cells of infected mice. Multiple organ-reactive monoclonal antibodies were produced in the wake of a reovirus infection.16–17 These studies also demonstrated that there are sometimes shared epitopes between the virus and host tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Yoon, J. W., 1983, Viruses in the pathogenesis of type I diabetes, Curr. Probl. Clin. Biochem. 12:11–44.

    PubMed  CAS  Google Scholar 

  2. Brogen, C. H., Baekkeskov, S., Dyrberg, T., Lenmark, A., Marner, B., Nerup, J., and Papadopoulos, G. K., 1983, Role of islet cell antibodies in the pathogenesis of type I diabetes, Curr. Probl. Clin. Biochem. 12:65–95.

    Google Scholar 

  3. Gepts, W., 1983, Role of cellular immunity in the pathogenesis of type I diabetes, Curr. Probl. Clin. Biochem. 12:86–107.

    PubMed  CAS  Google Scholar 

  4. Waksman, B. H., and Reynolds, W. E., 1984, Multiple sclerosis as a disease of immune regulation, Proc. Soc. Exp. Biol. Med. 175:282–294.

    PubMed  CAS  Google Scholar 

  5. Waksman, B. H., 1983, Immunity and nervous system: Basic tenets, Ann. Neurol. 13:517–591.

    Article  Google Scholar 

  6. Pini, M., Potli, R., and Dettori, A. G., 1982, Purpura thrombotic thrombocytopenia, Recent Prog. Med. 73:429–442.

    CAS  Google Scholar 

  7. Sherlock, S., 1984, Chronic hepatitis and cirrhosis, Hepatology 4:25–28.

    Article  Google Scholar 

  8. Moench, T. R., and Griffin, D. E., 1984, Immunocytochemical identification and quantification of the mononuclear cells in the cerebrospinal fluid, meninges and brain during acute viral meningoencephalomyelitis, J. Exp. Med. 159:77–88.

    Article  PubMed  CAS  Google Scholar 

  9. Johnson, R. T., Griffin, D. E., Hirsh, R. L. Wolinsky, J. S., Roedenbeck, S., Soriano, I. L. de, and Vaisberg, B., 1984, Measles encephalomyelitis—Clinical immunologic studies, N. Engl. J. Med. 310:137–141.

    Article  PubMed  CAS  Google Scholar 

  10. Abelman, W. H., 1971, Virus and the heart, Circulation 44:950–956.

    Google Scholar 

  11. Maisch, B., Berg, P. A., and Kochsiek, K., 1980, Autoantibodies and serum inhibition factors (SIF) in patients with myocarditis, Klin. Wochenschr, 58:219–225.

    Article  PubMed  CAS  Google Scholar 

  12. Maisch, B., Trostel-Soeder, R., Stechemesser, E., Berg, P. D., and Kochsiek, K., 1982, Diagnostic prevalence of humoral and cell-mediated immune reactions in patients with acute viral myocarditis, Circulation 70:149–156.

    Google Scholar 

  13. Yoon, J. W., and Notkins, A. L., 1976, Virus-induced diabetes mellitus. VI. Genetically determined host differences in the replication of encephalomyocarditis virus in pancreatic beta cells, J.Exp. Med. 143:1170–1185.

    Article  CAS  Google Scholar 

  14. Yoon, J. W., Onodera, T., and Notkins, A. L., 1978, Virus-induced diabetes mellitus. XV. Beta cell damage and insulin-dependent hyperglycemia in mice infected with Coxsackie virus B4,J.Exp. Med. 148:1068–1080.

    Article  PubMed  CAS  Google Scholar 

  15. Onodera, T., Tonioio, A., Ray, U. R., Jenson, A. B., Knazek, R. A., and Notkins, A. L., 1981, Virus-induced diabetes mellitus. XX. Polyendocrinopathy and autoimmunity,J.Exp. Med. 153:1457–1473.

    Article  PubMed  CAS  Google Scholar 

  16. Haspel, M. V., Onodera, T., Prabhakar, B. S., Horita, M. S., and Notkins, A. L., 1983, Virus-induced autoimmunity: Monoclonal antibodies that react with endocrine glands, Science 220:304–306.

    Article  PubMed  CAS  Google Scholar 

  17. Notkins, A. L., and Prabhakar, B. S., 1986, Monoclonal autoantibodies that react with multiple organs. Basis for reactivity, Ann. NY Acad. Sci 475:123–134.

    Article  PubMed  CAS  Google Scholar 

  18. Hirsh, M. S., and Proffitt, M. R., 1975, Autoimmunity in viral infections, in: Viral Immunology and Immunopathology (A. L. Notkins, ed.), pp. 419–434, Academic, New York.

    Google Scholar 

  19. Notkins, A. L., Onodera, T., and Prabhakar, B., 1984, Virus-induced autoimmunity, in: Concepts in Viral Pathogenesis (A. L. Notkins and M. B. A. Oldstone, eds.), pp. 210 – 215, Springer-Verlag, New York.

    Chapter  Google Scholar 

  20. Plotz, P. H., 1983, Autoantibodies are anti-idiotype antibodies to antiviral antibodies, Lancet 2:824–826.

    Article  PubMed  CAS  Google Scholar 

  21. Woodruff, J. F., 1970, Viral myocarditis, Am. J. Pathol. 101:427–479.

    Google Scholar 

  22. Sainani, G. S., Krompotic, E., and Slodki, S. J., 1968, Adult heart disease due to Coxsackie B infection, Medicine (Baltimore) 47:133–147.

    Article  CAS  Google Scholar 

  23. Cambridge, G., MacArthur, C. G. C., Waterson, A. P., Goodwin, J. F., and Oakley, C. M., 1979, Antibodies to Coxsackie B viruses in primary congestive cardiomyopathy, Br. Heart J. 41:692–696.

    Article  PubMed  CAS  Google Scholar 

  24. MacArthur, C. G. C., Tarin, D., Goodwin, J. F., and Hallidie-Smith, K. A., 1984, The relationship of myocarditis to dilated cardiomyopathy, Eur. Heart J. 5:1023–1035.

    PubMed  CAS  Google Scholar 

  25. Helin, M., Savola, J., and Lapinleimu, K., 1968, Cardiac manifestations during a Coxsackie B5 epidemic, Br. Med. J. 3:97–99.

    Article  PubMed  CAS  Google Scholar 

  26. Kaplan, M. H., and Frengley, J. D., 1969, Autoimmunity to the heart in cardiac disease, current concepts of the relation to autoimmunity to rheumatic fever, postcar-diotomy, and postinfarction syndromes and cardiomyopathies, Am. J. Cardiol. 24:459–473.

    Article  PubMed  CAS  Google Scholar 

  27. Maisch, B., Deeg, P., Liebau, G., and Kochsiek, K. 1976, Diagnostic relevance of humoral and cytotoxic immune reactions in primary and secondary dilated cardiomyopathy, Am. J. Cardiol. 52:1072–1078.

    Article  Google Scholar 

  28. Scheerder, I. de, Vandekerckhove, J., Robbrecht, J., Algoed, L., Buyzere, M. de, Langhe, J. de, Schrijver, G. de, and Clement, D., 1985, Post-cardiac injury syndrome and an increased humoral immune response against the major contractile proteins (actin and myosin), Am. J. Cardiol. 56:631–633.

    Article  PubMed  Google Scholar 

  29. Das, S. K., Callen, J. P., Dodson, V. N., and Cassidy, J. T., 1971, Immunoglobulin binding in cardiomyopathic hearts, Circulation 44:612–616.

    PubMed  CAS  Google Scholar 

  30. Schultheiss, H. P., and Boite, H. D., 1985, Immunological analysis of auto-antibodies against the adenine nucleotide translocator in dilated cardiomyopathy, J. Mol. Cell. Cardiol. 17:603–617.

    Article  PubMed  CAS  Google Scholar 

  31. Wong, C. Y., Woodruff, J. J., and Woodruff, J. F., 1977, Generation of cytotoxic T-lymphocytes during Coxsackie B3 infection. II. Characterization of effector cells and demonstration of cytotoxicity against viral-infected myocytes,J. Immunol. 118:1165–1169.

    PubMed  CAS  Google Scholar 

  32. Guthrie, M., Lodge, P. A., and Huber, S. A., 1984, Cardiac injury in myocarditis induced by Coxsackievirus group B in Balb/c mice is mediated by Lyt 2+ cytolytic lymphocytes, Cell. Immunol. 88:558–567.

    Article  PubMed  CAS  Google Scholar 

  33. Job, L. P., Lyden, D. C., and Huber, S. A., 1986, Demonstration of suppressor cells in Coxsackievirus group B, type 3 infected female Balb/c mice which prevent myocarditis, Cell. Immunol. 9:104–113.

    Article  Google Scholar 

  34. Huber, S. A., and Lodge, P. A., 1986, Coxsackievirus B-3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and Balb/c mice, Am. J. Pathol. 122:284–291.

    PubMed  CAS  Google Scholar 

  35. Khatib, R., Chason, J. L., Silberberg, B. K., and Lerner, A. M., 1980, Age-dependent myocardial pathogenesis of group B Coxsackievirus in Swiss-Webster mice: Comparisons to the pancreas,J. Infect. Dis. 141:394–401.

    Article  PubMed  CAS  Google Scholar 

  36. Gauntt, C. J., Trousdale, M. D., LaBadie, D. R. L., Paque, R. E., and Nealson, T., 1979, Properties of Coxsackievirus which are amyocarditic and myocarditic for mice,J. Med. Virol. 3:207–220.

    Article  PubMed  CAS  Google Scholar 

  37. Wolfgram, L. J., Beisel, K. W., and Rose, N. R., 1986, Variations in the susceptibility to Coxsackievirus B3-induced myocarditis among strains of mice,J. Immunol. 136:1846–1852.

    PubMed  CAS  Google Scholar 

  38. Herskowitz, A., Wolfgram, L. J., Rose, N. R., and Beisel, K. W., 1987, Coxsackievirus B3 murine myocarditis—Pathologic spectrum of myocarditis in genetically defined inbred strains,J.Am. Coll. Cardiol. 9:1311–1319.

    Article  PubMed  CAS  Google Scholar 

  39. Beisel, K., Wolfgram, L., Herskowitz, A., and Rose, N., 1985, Differences in severity of Coxsackievirus B3-induced myocarditis among H-2 congenic mouse strains, in: Genetic Control of Resistance to Infection and Malignancy (E. Skamene, ed.), pp. 195–201, Alan R. Liss, New York.

    Google Scholar 

  40. Wolfgram, L. J., Beisel, K. W., and Rose, N. R., 1985, Heart-specific autoantibodies following murine Coxsackievirus B3 myocarditis,J.Exp. Med. 161:1112–1121.

    Article  PubMed  CAS  Google Scholar 

  41. Matsumori, A., and Kawai, C., 1982, Animal model of congestive (dilated) cardiomyopathy: Dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus, Circulation 66:355–360.

    Article  PubMed  CAS  Google Scholar 

  42. Reyes, M. R., Khang-Loon, H., Smith, F., and Lerner, A. M., 1981, A mouse model of dilated-type cardiomyopathy due to Coxsackievirus B3,J. Infect. Dis. 144:232–236.

    Article  PubMed  CAS  Google Scholar 

  43. Alvarez, F. L., Neu, N., Rose, N. R., Craig, S. W., and Beisel, K. W., 1987, Heartspecific autoantibodies induced by Coxsackievirus B3: Identification of heart autoantigens, Clin. Immunol. Immunopathol. 43:129–139.

    Article  PubMed  CAS  Google Scholar 

  44. Neu, N., Beisel, K. W., Traystman, M. D., Rose, N. R., and Craig, S. W., 1987, Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis,J. Immunol. 138:2488–2492.

    PubMed  CAS  Google Scholar 

  45. Neu, N., Rose, N. R., Beisel, K. W., Herskowitz, A., Gurri-Glass, G., and Craig, S. W., 1987, Cardiac myosin induces myocarditis in genetically predisposed mice,J. Immunol. 139:3630–3636.

    PubMed  CAS  Google Scholar 

  46. Rose, N. R., Beisel, K. W., Herskowitz, A., Neu, N., Wolfgram, L. J., Alvarez, F. L., Traystman, M. D., and Craig, S. W., 1987’, Autoimmunity and Autoimmune Disease: Ciba Foundation Symposium 129 (D. Evered and J. Whelan, eds.), pp. 3–24, John Wiley & Sons, Chichester, England.

    Google Scholar 

  47. Beisel, K. W., Tharpe, J. A., Sell, K. W., Notkins, A. L., and Prabhakar, B. S., 1987, A monoclonal antibody against Coxsackievirus B4 which cross-reacts with the V1 isoform of myosin: implication for autoimmunity, J. Am. Coll. Cardiol. 9:145A.

    Google Scholar 

  48. Cunningham, M. W., Hall, N. K., Krisher, K. K., and Spanier, A. M., 1986, A study of anti-group A streptococcal monoclonal antibodies crossreactive with myosin,J. Immunol. 136:293–298.

    PubMed  CAS  Google Scholar 

  49. Dale, J. B., and Beachey, E. H., 1985, Epitopes of streptococcal M proteins shared with cardiac myosin,J.Exp. Med. 162:583–591.

    Article  PubMed  CAS  Google Scholar 

  50. Neu, N., Craig, S. W., Rose, N. R., Alvarez, F., and Beisel, K. W., 1987, Coxsackievirus-induced myocarditis in mice: Cardiac myosin autoantibodies do not crossreact with the virus, Clin. Exp. Immunol. 69:566–574.

    PubMed  CAS  Google Scholar 

  51. Wolfgram, L. J., 1986, Variations in the susceptibility to Coxsackievirus B3 induced myocarditis among different strains of mice, Ph.D. dissertation, Johns Hopkins University, Baltimore, Maryland.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, 30322, USA

    Kirk W. Beisel

  2. Department of Immunology and Infectious Diseases, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, 21205, USA

    Noel R. Rose

Authors
  1. Kirk W. Beisel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Noel R. Rose
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Beisel, K.W., Rose, N.R. (1988). Relationship of Coxsackievirus to Cardiac Autoimmunity. In: Bendinelli, M., Friedman, H. (eds) Coxsackieviruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0247-7_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0247-7_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0249-1

  • Online ISBN: 978-1-4757-0247-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation