Abstract
The coxsackieviruses (CV) are small, icosahedral positive single-stranded RNA viruses that cause common enteric infections in human populations throughout the world. Depending on virus type and factors such as age at infection, they may cause a wide spectrum of clinical diseases, including aseptic meningitis, common colds, epidemic myalgia (Bornholm disease), myocarditis, herpangina, pharyngitis, conjunctivitis, hand-foot-and-mouth disease, and possibly some cases of juvenile diabetes mellitus. CV were originally identified because of their pathogenicity for newborn mice and hamsters and were subsequently divided into two groups, A (CVA) and B (CVB), on the basis of differences in the tissue damage induced in these animals.
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Mahy, B.W.J. (1988). Classification and General Properties. In: Bendinelli, M., Friedman, H. (eds) Coxsackieviruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0247-7_1
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