Neuromodulatory Actions of Dopamine and Cholecystokinin in the Ventral Striatum
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Electrophysiological investigations of the cellular actions of dopamine had focused in the past on its direct action on cell bodies of the postsynaptic neuron, assuming dopamine to be a neuromediating transmitter. Recent evidence suggests, however, that while dopamine undoubtedly has actions on the cell bodies of postsynaptic neurons, it may also have an important presynaptic neuromodulatory action on non-dopaminergic inputs to the ventral striatum (see Yim and Mogenson, 1986). There is also evidence that peptides such as cholecystokinin which coexists with dopamine in a subpopulation of the mesolimbic dopamine neurons may in turn modulate the neuromodulatory action of dopamine.
KeywordsLocomotor Activity Nucleus Accumbens Ventral Tegmental Area Ventral Striatum Excitatory Response
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