Substance P Excites Cultured Cholinergic Neurons in the Basal Forebrain

  • Yasuko Nakajima
  • Peter R. Stanfield
  • Kazuhiko Yamaguchi
  • Shigehiro Nakajima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 295)


With the introduction of choline acetyltransferase immunocytochemistry, it has recently been shown that there are nuclei containing cholinergic neurons in the basal forebrain, which innervate wide areas of the cerebral cortex and hippocampus. These basal forebrain nuclei include the nucleus basalis of Meynert, the medial septal nucleus and the diagonal band nuclei. These cholinergic neurons in the basal forebrain nuclei severely degenerate in patients with Alzheimer’s disease (Coyle et al., 1983; Terry and Katzman, 1983). Despite their clinical importance, physiological and pharmacological properties of these cholinergic neurons are not well understood.


Basal Forebrain Pertussis Toxin Nucleus Basalis Potassium Conductance Locus Coeruleus Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Yasuko Nakajima
    • 1
  • Peter R. Stanfield
    • 1
  • Kazuhiko Yamaguchi
    • 1
  • Shigehiro Nakajima
    • 1
  1. 1.Department of Biological SciencesPurdue UniversityWest LafayetteUSA

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