γ-Aminobutyric Acid and µ-Opioid Receptor Localization and Adaptation in the Basal Forebrain
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The projection from the nucleus accumbens to ventral pallidum has been functionally implicated in the integration of motivation and locomotion, since the limbic system and the extrapyramidal motor system interconnect in this projection (Mogenson et al., 1980). The nucleus accumbens receives innervation from dopaminergic neurons in the ventral tegmental area and substantia nigra (Fallon and Moore, 1978; Gerfen et al., 1987) and projects topographically onto the ventral pallidum (Conrad and Pfaff, 197 6; Nauta et al., 1978; Mogenson et al., 1983; Groenewegen and Russchen, 1984). The projection from nucleus accumbens to ventral pallidum appears to contain γ-aminobutyric acid (GABA) and enkephalin. Electrolytic lesions of the nucleus accumbens significantly decreased glutamic acid decarboxylase (GAD), the synthetic enzyme for GABA, in the ventral pallidum (Walaas and Fonnum, 1979) and ibotenic acid lesions of the nucleus accumbens significantly decreased enkephalin-like immunoreactivity in the ventral pallidum (Zaborszky et al., 1985).
KeywordsNucleus Accumbens GABAA Receptor Globus Pallidus Basal Forebrain Glutamic Acid Decarboxylase
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