Abstract
There are a wide variety of chemical substances that have been classified as abused drugs on the basis of their excessive or inappropriate use. Although they may have distinct neurochemical actions and come from different pharmacological classes, what these drugs have in common is their capacity to engender pleasurable feelings or sensations in those individuals that use them. It is commonly believed that it is this property, their euphorigenic action, that causes their abuse.
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References
Bozarth, M.A. and Wise, R.A., 1981, Intracranial self-administration of morphine into the ventral tegmental area in rats, Life Sci., 28:551.
Dworkin, S.I., Goeders, N.E., Guerin, G.F., Co, C., and Smith, J.E., 1988a, Effects of 5,7-dihydoxytrptamine lesions of the nucleus accumbens in rats responding on a concurrent schedule of food, water, and intravenous morphine self-administration, in: “Problems of drug dependence,” L. Harris, ed., NIDA Research Monograph No. 81, Washington, D.C., p. 138.
Dworkin, S.I., Guerin, G.F., Co, C., Goeders, N.E., and Smith, J.E., 1988b, Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration, Pharmacol. Biochem. Behav., 30:1051.
Dworkin, S.I., Guerin, G.F., Goeders, N.E., and Smith, J.E., 1988c, Kainic acid lesions of the nucleus accumbens selectively attenuate morphine self-administration, Pharmacol. Biochem. Behav., 29:175.
Glick, S.D., 1973, Impaired tolerance to the effects of oral amphetamine intake in rats with frontal cortex ablations, Psychopharmacology. 28:363.
Glick, S.D., 1974, Changes in sensitivity to the rewarding property of morphine following lesions of the medial forebrain bundle or caudate nucleus in rats. Arch. Int. Pharmacodvn. Therap., 212:214.
Glick, S.D. and Cox, R.D., 1977, Changes in morphine self-administration after brainstem lesions in rats, Psychopharmacology. 52:151.
Glick, S.D. and Cox, R.D., 1978, Changes in morphine self-administration after tel-diencephalic lesions in rats, Psychopharmacology. 57:283.
Glick, S.D. and Marsanico, R.G., 1975, Time-dependent changes in amphetamine self-administration following frontal cortex ablations in rats, J. Comp. Physiol. Psychol., 88:355.
Glick, S.D., Cox, R.D., and Crane, A.M., 1975, Changes in morphine self-administration and morphine dependence after lesions of the caudate nucleus in rats, Psychopharmacology. 41:219.
Goeders, N.E. and Smith, J.E., 1983, Cortical dopaminergic involvement in cocaine reinforcement, Science. 221:773.
Goeders, N.E., Dworkin, S.I., and Smith, J.E., 1986, Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex, Pharmacol. Biochem. Behav., 24:1429.
Goeders, N.E., Lane, J.D., and Smith, J.E., 1984, Intracranial self-administration of methionine enkephalin into the nucleus accumbens, Pharmacol. Biochem. Behav., 20:451.
Hoebel, B.G., Monaco, A.P., Hernandez, L., Aulisi, E.F., Stanly, B.C., and Lenard, L., 1983, Self-injection of amphetamine directly into the brain, Psychopharmacology. 81:158.
Hubner, C.B. and Koob, G.F., 1990, The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat. Brain Res., 508:20.
Koob, G.F. and Goeders, N.E., 1989, Neuroanatomical substrates of drug self-administration, in: “The Neuropharmacological Basis of Reward,” J.M. Liebman and S.J. Cooper, ed., Clarendon Press, Oxford, p. 214.
Koob, G.F., Vaccarino, F.J., Amalric, M., and Bloom, F.E., 1987, Positive reinforcement properties of drugs: search for neural substrates, in: “Brain reward systems and abuse,” J. Engel and L. Oreland, ed., Raven, New York, p. 35.
Lyness, W.H., Friedle, N.M., and Moore, K.E., 1979, Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration, Pharmacol. Biochem. Behav., 11:553.
Lyness, W.H., Friedle, N.M., and Moore, K.E., 1980, Increased self- administration of d-amphetamine after destruction of 5- hydroxytryptaminergic neurons, Pharmacol. Biochem. Behav., 12:937.
Martin-Iverson, M.T., Szostak, C., and Fibiger, H.C., 1986, 6-Hydroxydopamine lesions of the medial prefrontal cortex fail to influence intravenous self-administration of cocaine, Psychopharmacologv. 88:310.
Olds, M.E., 1979, Hypothalamic substrate for the positive reinforcing properties of morphine in the rat. Brain Res., 168:351.
Olds, M.E., 1982, Reinforcing effects of morphine in the nucleus accumbens. Brain Res., 237:429.
Olds, M.E. and Williams, K.N., 1980, Self-administration of D-Ala-Metenkephalinamide at hypothalamic self-stimulation sites. Brain Res., 194:155.
Pettit, H.O., Ettenberg, A., Bloom, F.E., and Koob, G.F., 1984, Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats, Psychopharmacology, 84:167.
Phillips, A.G. and Rolls, E.T., 1981, Intracranial self-administration of amphetamine by rhesus monkeys, Neurosci. Lett., 24:81.
Pontieri F.E., Crane, A.M., Seiden, L.S., Kleven, M.S., and Porrino, L.J., Metabolic mapping of the effects of intravenous methamphetamine administration in freely-moving rats. Psychopharmacology. in Press.
Porrino, L.J., Domer, F.R., Crane, A.M., and Sokoloff, L., 1988, Selective alterations in cerebral metabolism within the mesocorticolimbic dopaminergic system produced by acute cocaine administration in rat, Neuropsychopharmacology, 1:109.
Porrino, L.J., Esposito, R.U., Seeger, T.F., Crane A.M., Pert, A., and Sokploff, L., 1984, Metabolic mapping of the brain during rewarding self-stimulation. Science. 224:306.
Roberts, D.C.S. and Koob, G.F., 1982, Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats, Pharmacol. Biochem. Behav., 17:901.
Roberts, D.C.S., Koob, G.F., Klonoff, P., and Fibiger, H.C., 1980, Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens, Pharmacol. Biochem. Behav., 12:781.
Smith, J.E., Co, C., and Lane, J.D., 1984a, Limbic acetylcholine turnover rates correlated with rat morphine-seeking behaviors, Pharmacol. Biochem. Behav., 20:429.
Smith, J.E., Co, C., and Lane, J.D., 1984b, Limbic muscarinic and benzodiazepine receptor changes with chronic intravenous morphine and self-administration, Pharmacol. Biochem. Behav., 20:443–450.
Smith, J.E., Co, C., Freeman, M.E., and Lane, J.D., 1982, Brain neurotransmitter turnover correlated with morphine-seeking behavior of rats, Pharmacol. Biochem. Behav., 16:509.
Smith, J.E., Dworkin, S.I., Co, C., and Porrino, L.J., 1990, Concurrent brain glucose utilization and biogenic monoamine neurotransmitter turnover rates with VTA brain stimulation reinforcement. Soc. Neurosci. Abstr. 19, in press.
Smith, J.E., Guerin, G.F., Co, C., Barr, T.S., and Lane, J.D., 1985, Effects of 6-OHDA lesions of the central medial nucleus accumbens on rat intravenous morphine self-administration, Pharmacol. Biochem. Behav., 23:843.
Smith, J.E., Shultz, K., Co, C., Goeders, N.E., and Dworkin, S.I., 1987, Effects of 5,7-dihydrotryptamine lesions of the nucleus accumbens on rat intravenous morphine self-administration, Pharmacol. Biochem. Behav., 26:607.
Sokoloff, L., Reivich, M., Kennedy, C., DesRosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O., and Shinohara, M., 1977, The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897.
Trafton, C.L. and Marques, P.R., 1971, Effects of septal area and cingulate cortex lesions on opiate addiction behavior in rats, J. Comp Physiol. Psychol., 75:227.
Weeks, J.R., 1962, Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats, Science, 138:143.
Zito, K.A., Vickers, G., and Roberts, D.C.S., 1985, Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens, Pharmacol. Biochem. Behav., 23:1029.
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© 1991 Plenum Press, New York
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Porrino, L.J., Dworkin, S.I., Smith, J.E. (1991). Basal Forebrain Involvement in Self-Administration of Drugs of Abuse. In: Napier, T.C., Kalivas, P.W., Hanin, I. (eds) The Basal Forebrain. Advances in Experimental Medicine and Biology, vol 295. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0145-6_19
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DOI: https://doi.org/10.1007/978-1-4757-0145-6_19
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