Basal Forebrain Involvement in Self-Administration of Drugs of Abuse

  • Linda J. Porrino
  • Steven I. Dworkin
  • James E. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 295)


There are a wide variety of chemical substances that have been classified as abused drugs on the basis of their excessive or inappropriate use. Although they may have distinct neurochemical actions and come from different pharmacological classes, what these drugs have in common is their capacity to engender pleasurable feelings or sensations in those individuals that use them. It is commonly believed that it is this property, their euphorigenic action, that causes their abuse.


Nucleus Accumbens Ventral Tegmental Area Medial Prefrontal Cortex Brain Stimulation Reward Neuroanatomical Substrate 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Linda J. Porrino
    • 1
    • 2
  • Steven I. Dworkin
    • 1
    • 2
  • James E. Smith
    • 1
    • 2
  1. 1.Unit on Brain ImagingNINDSBethesdaUSA
  2. 2.Department of Physiology and Pharmacology, Bowman-Gray School of MedicineWake Forest UniversityWinston-SalemUSA

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