Basal Forebrain Modulation of Cortical Cell Activity During Conditioning

  • James Pirch
  • Greg Rigdon
  • Hubert Rucker
  • Kathy Turco
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 295)


Several investigators have found that basal forebrain neurons in the area of the nucleus basalis and substantia innominata respond to cues that signal the availability of reinforcement (DeLong, 1971; Mitchell et al., 1987; Richardson and DeLong, 1986, 1988; Rolls et al., 1979; Travis and Sparks, 1968; Wilson and Rolls, 1990a, 1990b). The reinforcement-related or conditioning-related responses of such basal forebrain neurons do not depend upon the sensory modality of the signal cue (Wilson and Rolls, 1990a). It is also known that cortical neurons respond to conditioned stimuli applied during similar behavioral paradigms (Aou et al., 1983; Boyd et al., 1982; Fuster et al., 1982; Kojima and Goldman-Rakic, 1982; Mauritz and Wise, 1986; Peterson, 1986; Watanabe, 1990), suggesting a possible relationship between cortical neuron responses and activity of basal forebrain neurons.


Conditioned Stimulus Basal Forebrain Nucleus Basalis Substantia Innominata Basal Forebrain Neuron 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James Pirch
    • 1
  • Greg Rigdon
    • 1
  • Hubert Rucker
    • 1
  • Kathy Turco
    • 1
  1. 1.Department of PharmacologyTexas Tech University Health Sciences CenterLubbockUSA

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