Abstract
Early detection of ovarian cancer might substantially improve results of therapy. After careful surgical staging, 90% of patients with stage I disease and 70% of patients with stage II disease can be cured with currently available therapy. Epithelial ovarian cancer may be one of the malignancies that lends itself to early detection with a blood test. Antigens shed from the ovarian surface into the peritoneal cavity are taken up by diaphragmatic lymphatics and pass through the alternative thoracic duct into the venous circulation. In early work by Knauf and Urbach [1] the OCA antigen could be detected in 70% of patients with early stage disease. OCA was also found in approximately 10% of healthy individuals, precluding its use in screening. This observation did, however, suggest that shed tumor products could be found in the circulation in an early stage of disease.
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Bast, R.C. et al. (1995). Complementary and coordinate markers for detection of epithelial ovarian cancers. In: Sharp, F., Mason, P., Blackett, T., Berek, J. (eds) Ovarian Cancer 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0136-4_19
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DOI: https://doi.org/10.1007/978-1-4757-0136-4_19
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