Abstract
In terms of everyday experience, we think of disease and illness as something visited upon a healthy body from the outside; analogous to an unfortunate accident. Microbes infect us, and plagues and epidemics come upon us. In this way, man has come to view illness as an event that is discontinuous with normal function. However, normal processes can go awry without particular help from outside agents and produce disease and illness. In this circumstance, the line between the normal and abnormal can often be hard to discern, and the old adage that there can be too much (or too little) of a good thing may apply. Thus, we have come to appreciate that disease is often continuous with, rather than a break and something different from, normal function.
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References
Adelson, J. W. and Miller, P. E. (1985), Pancreatic secretion by nonparallel exocytosis: potential resolution of a long controversy. Science, 228, 993–996.
Adelson, J. W. and Rothman, S. S. (1974). Selective pancreatic enzyme secretion due to a new peptide called chymodenin. Science, 183, 1087–1089.
Applegarth, A., Furuta, F. and Lepkovsky, S. (1964). Response of the chicken pancreas to raw soybean. Poultry Sci., 43, 733–739.
Chernick, S. S., Lepkovsky, S., and Chaikoff, I. L. (1948). A dietary factor regulating the enzyme content of the pancreas: changes induced in size and proteolytic activity of the chick pancreas by the ingestion of raw soybean meal. Am. J. Physiol., 155: 33–41.
Dick, J. and Felber, J.P. (1975).Specific hormonal regulation, by food, of the pancreas enzymatic (amylase and trypsin) secretion. Horm. Metab. Res., 7, 161–166.
Felber, J. P., Zermatten, A. and Dick, J. (1974). Modulation, by food, of hormonal system regulating rat pancreatic secretion. Lancet, 2, 185–188.
Green, G. M. and Lyman, R. L. (1972). Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor-induced hypersecretion in rats. Proc. Soc. Exp. Biol. Med., 140, 6–12.
Green, T. R. and Ryan, C. A. (1972). Wound-induced proteinase inhibitor in plant leaves: a possible defense mechanism against insects. Science, 175, 776–777. See also, Brown et al., this volume.
Grendell, J. H. (1985). Nonparallel secretion of digestive enzyme by the pancreas — implications for models for protein secretion. In “Nonvesicular Transport,” S. S. Rothman and J. J. J. Ho, eds., John Wiley & Sons, New York, pp. 347–3
Grendell, J. H. and Rothman, S. S. (1981). Digestive end products mobilize secretory proteins from subcellular stores in the pancreas. Am. J. Physiol., 241, G67–G73.
Grendell, J. H., Tseng, H. C. and Rothman, S. S. (1984). Regulation of digestion. I. Effects of glucose and lysine on pancreatic secretion. Am. J. Physiol., 246, G445–G450.
Grossman, M. I., Greengard, H. and Ivy, A. C. (1943). The effect of dietary composition on pancreatic enzymes. Am. J. Physiol., 138, 676–682.
Khayambashi, H. and Lyman, R. L. (1966). Growth depression and pancreatic and intestinal changes in rats force-fed amino acid diets containing soybean trypsin inhibitor. J. Nutr., 89, 455–464.
Laskowski, M., Jr., and Kato, I. (1980). Protein inhibitors of proteinases. Ann. Rev. Biochem., 49, 593–626.
Lyman, R. L. and Lepkovsky, S. (1957). The effect of raw soybean meal and trypsin inhibitor diets on pancreatic enzyme secretion in the rat. J. Nutr., 62, 269–284.
Rackis, J. J. (1974). Biological and physiological factors in soybeans. J. Am. Oil Chem. Soc, 51, 161A–174A.
Reisenauer A. and Gray, G. M. (1985). Abrupt induction of a membrane digestive enzyme by its intraintestinal substrate. Science, 227, 70–72.
Rothman, S. S. (1974). Molecular regulation of digestion: short-term and bond specific. Am. J. Physiol., 226, 77–83
Rothman, S. S. (1977). The digestive enzymes of the pancreas: a mixture of inconstant proportions. Ann. Rev. Physiol., 39, 373–389.
Rothman, S. S. (1985). “Protein Secretion: A Critical Analysis of the Vesicle Model”. John Wiley & Sons, New York.
Rothman, S. S. and Wells, H. (1969). Selective effects of dietary egg white trypsin inhibitor on pancreatic enzyme secretion. Am. J. Physiol., 216, 504–507.
Schneeman, B. O. and Lyman, R. L. (1975). Factors involved in the intestinal feedback regulation of pancreatic enzyme secretion in the rat. Proc. Soc. Exp. Biol. Med., 148, 897–903.
Tseng, H. C., Grendell, J. H. and Rothman, S. S. (1984). Regulation of digestion. II. Effects of insulin and glucagon on pancreatic secretion. Am. J. Physiol., 246, G451–G456.
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© 1986 Plenum Press, New York
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Rothman, S.S. (1986). The Biological Functions and Physiological Effects of Ingested Inhibitors of Digestive Reactions. In: Friedman, M. (eds) Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Advances in Experimental Medicine and Biology, vol 199. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0022-0_2
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DOI: https://doi.org/10.1007/978-1-4757-0022-0_2
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