Regulation of Liver Plasma Membrane Ca2+ Pump

  • Sophie Lotersztajn
  • Catherine Pavoine
  • Ariane Mallat
  • Françoise Pecker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 232)


In mammalian tissues, Na2+/Ca2+ exchange and ATP-dependent Ca2+ pump supported by a (Ca2+-Mg2+)ATPase, both located in the plasma membranes, are the two mechanisms responsible for extrusion of Ca2+ out of the cell against its electrochemical gradient (for a review, see ref. 1). The extracellular free Ca2+ concentration is about 104 times that of intracellular free Ca2+ (50–200 nM). Therefore, the maintenance of a low intracellular free Ca2+ level is critical to preserve the integrity of the cell and its responsiveness to multiple external stimuli. It is now well established that a wide variety of hormones and neurotransmitters exert their effects by mobilizing Ca2+ from intracellular stores, namely endoplasmic reticulum1. The resulting increase in free cytosolic Ca2+ is supposed to be the signal which initiates cellular responses1. However, considering the limited capacity of intracellular stores and the maintenance of elevated Ca2+ after the stimulus, one may assume that inhibition of the liver Ca2+ pump by Ca2+ mobilizing hormones explain the prolonged physiological responses. The purpose of the present report is to make the point on our recent results concerning the liver plasma membrane Ca2+ pump and its regulation.


ATPase Activity Adenylate Cyclase Cholera Toxin Phospholipid Vesicle Liver Plasma Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Sophie Lotersztajn
    • 1
  • Catherine Pavoine
    • 1
  • Ariane Mallat
    • 1
  • Françoise Pecker
    • 1
  1. 1.Unité INSERM 99 hôpital Henri MondorCréteilFrance

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