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AGEPC: A Potent Calcium-Dependent Chemical Mediator in the Liver

  • Chapter
Cellular Ca2+ Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 232))

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Abstract

AGEPC (i.e. 1-0-alkyl-2-acetyl- sn -glycero-3-phosphocholine) or platelet activating factor is a unique phosphoglyceride first described as a fluid phase mediator of platelet aggregation during immunoglobulin E-induced anaphylaxis in the rabbit (1,2). AGEPC is produced in response to various stimuli in a variety of cells including neutrophils, basophils, monocytes and mast cells (3-7), and is among the most potent mediators formed and released by biological tissues. AGEPC induces aggregation and degranulation of platelets and neutrophils at subnanomolar concentrations (8,9) and is thought to act by interaction with specific receptors (10–13). In platelets, AGEPC-induced aggregation is associated with the turnover of inositol phospholipids, production of phosphatidic acid and protein phosphorylation (12–15). Additional studies have indicated that AGEPC possesses diverse biological actions including contraction of smooth muscles (16–18), negative inotropic cardiac effects (19,20), vasoconstriction (21,22), and exocrine gland stimulation (23). We have recently found that AGEPC possesses a powerful regulatory effect on hepatic metabolism which is the subject of this report.

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References

  1. Sirganian, R.P., and Osler, A.G. (1971) J. Immunol. 106, 1244–1251.

    Google Scholar 

  2. Benveniste, J., Henson, P.M., and Cochrane, C.G. (1972) J. Exp. Med. 136, 1356–1377.

    Article  PubMed  CAS  Google Scholar 

  3. Lotner, G.Z., Lynch, J.M., and Henson, P.M. (1980) J. Immunol. 124, 676–684.

    PubMed  CAS  Google Scholar 

  4. Clark, P.O., Hanahan, D.J., and Pinckard, R.N. (1980) Biochim. Biophys. Acta 628, 69–75.

    Article  PubMed  CAS  Google Scholar 

  5. Camussi, G., Mencia-Huerta, J.M., and Benveniste, J. (1977) Immunology 33, 523–534.

    PubMed  CAS  Google Scholar 

  6. Pinckard, R.N., Farr, R.S., and Hanahan, D.J. (1979) J. Immunol. 123, 1847–1857.

    PubMed  CAS  Google Scholar 

  7. Lynch, J.M., Lotner, G.Z., Betz, S.J., and Henson, P.M. (1979) J. Immunol. 123, 1219–1226.

    PubMed  CAS  Google Scholar 

  8. Demopoulos, CA., Pinckard, R.N., and Hanahan, D.J. (1979) J. Biol. Chem. 254, 9355–9358.

    PubMed  CAS  Google Scholar 

  9. O’Flaherty, J.T., Wykle, R.L., Miller, CH., Lewis, J.C, Waite, M., Bass, D.A., McCall, CE., and DeChatelet, L.R. (1981) Am. J. Pathol. 103, 70–79.

    PubMed  Google Scholar 

  10. Valone, F.H., Coles, E., Reinhold, V.R., and Goetzl, E.J. (1982) J. Immunol. 129, 1637–1641.

    PubMed  CAS  Google Scholar 

  11. Hwang, S.-B., Lee, C.-S.C, Cheah, M.J., and Shen, T.Y. (1983) Biochemistry 22, 4756–4763.

    Article  PubMed  CAS  Google Scholar 

  12. Tokumura, A., Homma, H., and Hanahan, D.J. (1985) J. Biol. Chem. 260, 12710–12714.

    PubMed  CAS  Google Scholar 

  13. Sugatani, J., and Hanahan, D.J. (1986) Arch. Biochem. Biophys. 246, 855–864.

    Article  PubMed  CAS  Google Scholar 

  14. Lapetina, E.G., and Siegel, F.L. (1983) J. Biol. Chem. 258, 7241–7244.

    PubMed  CAS  Google Scholar 

  15. Shukla, S.D., and Hanahan, D.J. (1982) Biochem. Biophys. Res. Commun. 106, 697–703.

    Article  PubMed  CAS  Google Scholar 

  16. Findlay, S.R., Lichtenstein, L.M., Hanahan, D.J., and Pinckard, R.N. (1981) Am. J. Physiol. 241, 130–134.

    Google Scholar 

  17. Tokumura, A., Fukuzawa, K., and Tsukatani, H. (1984) J. Pharm. Pharmacol. 36, 210–212.

    Article  PubMed  CAS  Google Scholar 

  18. Kester, M., Ledvora, R.F., and Barany, M. (1984) Eur. J. Physiol. Pflugers Arch. 400, 200–202.

    Article  CAS  Google Scholar 

  19. Levi, R., Burke, J.A., Guo, Z.-C, Hattori, Y., Hoppens, CM., McManus, L.M., Hanahan, D.J., and Pinckard, R.N. (1984) Circ. Res. 54, 117–124.

    Article  PubMed  CAS  Google Scholar 

  20. Benveniste, J., Boullet, C., Brink, C., and Labat, C (1983) Br. J. Pharmacol. 80, 81–83.

    Article  PubMed  CAS  Google Scholar 

  21. Bjork, J., and Smedegard, G. (1983) Eur. J. Pharmacol. 96, 87–94.

    Article  PubMed  CAS  Google Scholar 

  22. Buxton, D.B., Fisher, R.A., Hanahan, D.J., and Olson, M.S. (1986) J. Biol. Chem. 261, 644–649.

    PubMed  CAS  Google Scholar 

  23. Soling, H.-D., Eibl, H., and Fest, W. (1984) Eur. J. Biochem. 144, 65–72.

    Article  PubMed  CAS  Google Scholar 

  24. Lapetina, E.G. (1982) J. Biol. Chem. 257, 7314–7317.

    PubMed  CAS  Google Scholar 

  25. Michell, R.H., Kirk, C.J., Jones, L.M., Downes, C.P., and Creba, J.A. (1981) Phil. Trans. R. Soc. B296, 123–137.

    Google Scholar 

  26. Creba, J.A., Downes, C.P., Hawkins, P.T., Brewster, G., Michell, R.H., and Kirk, C.J. (1983) Biochem. J. 212, 733–747.

    PubMed  CAS  Google Scholar 

  27. Thomas, A.P., Alexander, J., and Williamson, J.R. (1984) J. Biol. Chem. 259, 5574–5584.

    PubMed  CAS  Google Scholar 

  28. Joseph, S.K., Thomas, A.P., Williams, R.J., Irvine, R.F., and Williamson, J.R. (1984) 259, 3077–3081.

    Google Scholar 

  29. Burgess, G.M., Godfrey, P.P., McKinney, J.S., Berridge, M.J., Irvine, R.F., and Putney, J.W. (1984) Nature 309, 63–66.

    Article  PubMed  CAS  Google Scholar 

  30. Charest, R., Prpic, V., Exton, J.H., and Blackmore, P.F. (1985) Biochem. J. 227, 79–90.

    PubMed  CAS  Google Scholar 

  31. Shaw, J.O., Klusick, S.J., and Hanahan, D.J. (1981) Biochim. Biophys. Acta 663, 222–229.

    Article  PubMed  CAS  Google Scholar 

  32. Hill, C.E., Olson, M.S., Sheridan, P.J., and Hanahan, D.J. (1985) Fed. Proc. 44, 480.

    Google Scholar 

  33. Blackmore, P.F., Dehaye, J.-P., and Exton, J.H. (1979) J. Biol. Chem. 254, 6945–6950.

    PubMed  CAS  Google Scholar 

  34. Althaus-Salzman, M., Carafoli, E., and Jakob, A. (1980) Eur. J. Biochem. 106, 241–248.

    Article  Google Scholar 

  35. Chesney, C.M., Pifer, D.D., and Huch, K.M. (1983) INSERM Symp. 23, 177–184.

    CAS  Google Scholar 

  36. Blackmore, P.F., Brumley, F.T., Marks, J.L., and Exton, J.H. (1978) J. Biol. Chem. 253, 4851–4858.

    PubMed  CAS  Google Scholar 

  37. Chen, J.-L.J., Babcock, D.F., and Lardy, H.A. (1978) Proc. Natl. Acad. Sci. 75, 2234–2238.

    Article  PubMed  CAS  Google Scholar 

  38. Exton, J.H. (1983) in “Calcium and Cell Function” (Cheung, W.Y., ed.) Vol IV, pp 63–97, Academic Press, New York.

    Google Scholar 

  39. Bussolino, F., Aglietta, M., Sanavio, F., Stacchini, A., Lauri, D., and Camussi, G. (1985) J. Immunol. 135, 2748–2753.

    PubMed  CAS  Google Scholar 

  40. Bessin, P., Bonnet, J., Apffel, D., Soulard, C., Desgroux, L., Pelas, I., and Benveniste, J. (1983) Eur. J. Pharmacol. 86, 403–413.

    Article  PubMed  CAS  Google Scholar 

  41. Goldstein, B.M., Gabel, R.A., Huggins, F.J., Cervoni, P., and Crandall, D.L. (1984) Life Sci. 35, 1373–1378.

    Article  PubMed  CAS  Google Scholar 

  42. Maegraith, B.G., Andrews, W.H.H., and Wenyon, C.E.M. (1949) Lancet 2, 56–57.

    Article  PubMed  CAS  Google Scholar 

  43. McCuskey, R.S. (1966) Am. J. Anat. 119, 455–477.

    Article  PubMed  CAS  Google Scholar 

  44. Rappaport, A.M. (1973) Microvas. Res. 5, 212–228.

    Article  Google Scholar 

  45. Hems, D.A., and Whitton, P.D. (1980) Physiol. Rev. 60, 1–50.

    PubMed  CAS  Google Scholar 

  46. Hers, H.G. (1976) Ann. Rev. Biochem. 45, 167–189.

    Article  PubMed  CAS  Google Scholar 

  47. Hems, D.A., and Brosnan, J.T. (1970) Biochem. J. 120, 105–111.

    PubMed  CAS  Google Scholar 

  48. Faupel, R.P., Seitz, H.J., and Tarnowski, W. (1972) Arch. Biochem. Biophys. 148, 509–522.

    Article  PubMed  CAS  Google Scholar 

  49. Buxton, D.B., Shukla, S.D., Hanahan, D.J., and Olson, M.S. (1984) 259, 1468-1471.

    Google Scholar 

  50. Koo, A., Liang, I.Y.S., and Cheng, K.K. (1976) Clin. Exp. Pharmacol. Physiol. 3, 391–395.

    Article  PubMed  CAS  Google Scholar 

  51. Reilly, F.D., McCuskey, R.S., and Cilento, E.V. (1981) Microvas. Res. 21, 103–116.

    Article  CAS  Google Scholar 

  52. Koo, A., Tse, T.-F., and Yu, D.Y.C. (1979) Clin. Exp. Pharmacol. 6, 495–506.

    Article  CAS  Google Scholar 

  53. Ljung, B., Isaksson, O., and Johansson, B. (1975) Acta Physiol. Scand. 94, 154–166.

    Article  PubMed  CAS  Google Scholar 

  54. Fisher, R.A., Kumar, R., Hanahan, D.J., and Olson, M.S. (1986) J. Biol. Chem. 261, 8817–8823.

    PubMed  CAS  Google Scholar 

  55. Blair, J.B., James, M.E., and Foster, J.L. (1979) J. Biol. Chem. 254, 7579–7584.

    PubMed  CAS  Google Scholar 

  56. Morgan, N.G., Blackmore, P.F., and Exton, J.H. (1983) J. Biol. Chem. 258, 5103–5109.

    PubMed  CAS  Google Scholar 

  57. Pinckard, R.N., Farr, R.S., and Hanahan, D.J. (1979) J. Immunol. 123, 1847–1857.

    PubMed  CAS  Google Scholar 

  58. Camussi, G., Tetta, C., Deregibus, M.C., Bussolino, F., Segoloni, G., and Vercellone, A. (1982) J. Immunol. 128, 86–94.

    Google Scholar 

  59. Buxton, D.B., Hanahan, D.J., and Olson, M.S. (1984) J. Biol. Chem. 259, 13758–13761.

    PubMed  CAS  Google Scholar 

  60. Fisher, R.A., Kumar, R., Hanahan, D.J., and Olson, M.S. (1986) Fed. Proc. 45, 1838.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas, USA

    Rory A. Fisher, Denis B. Buxton, David S. Lapointe, Donald J. Hanahan & Merle S. Olson

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  1. Rory A. Fisher
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  2. Denis B. Buxton
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  3. David S. Lapointe
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  4. Donald J. Hanahan
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  5. Merle S. Olson
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Editors and Affiliations

  1. Hormel Institute, University of Minnesota, Austin, Minnesota, USA

    Douglas R. Pfeiffer

  2. Department of Medicine, University of Alabama, Birmingham, Alabama, USA

    Jeanie B. McMillin

  3. Beckman Instruments, Palo Alto, California, USA

    Steve Little

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© 1988 Plenum Press, New York

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Fisher, R.A., Buxton, D.B., Lapointe, D.S., Hanahan, D.J., Olson, M.S. (1988). AGEPC: A Potent Calcium-Dependent Chemical Mediator in the Liver. In: Pfeiffer, D.R., McMillin, J.B., Little, S. (eds) Cellular Ca2+ Regulation. Advances in Experimental Medicine and Biology, vol 232. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0007-7_22

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  • DOI: https://doi.org/10.1007/978-1-4757-0007-7_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0009-1

  • Online ISBN: 978-1-4757-0007-7

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