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In Vivo Regulation by Estradiol of the Messenger RNAs Encoding LH and FSH Subunits and the Secretion of Gonadotropins

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Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Gonadotropins are glycoproteins composed of two dissimilar, non-covalently linked α- and β-subunits. Within a given species, the amino acid sequences of the α-subunits of LH and FSH are identical, while those of the hormone specific β-subunits differ (Pierce and Parsons, 1981).

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References

  • Alexander, D.C., and Miller, W.L., 1982, Regulation of ovine follicle-stimulating hormone 0-chain mRNA by 170-estradiol in vivo and in vitro. J. Biol. Chem., 257: 2282–2286.

    PubMed  CAS  Google Scholar 

  • Aubert, M.L., Conne, B.S., Winniger, B.P., Lang, U., and Sizonenko, P.C., 1983, Hormonal regulations of pituitary GnRH binding sites, in “Multihormonal Regulations in Neuroendocrine Cells”, A. Tixier-Vidal and P. Richard, eds., pp.319–346, INSERM, Paris (INSERM Symposium no 110, Colmar, France, 1–4 september 1982 ).

    Google Scholar 

  • Chin, W.W., Godine, J.E., Klein, D.R., Chang, A.S., Lee, K.T., and Habener, J.F., 1983, Nucleotide sequence of the cDNA encoding the precursor of the 0 subunit of rat lutropin, Proc. Natl. Acad. Sci. USA, 80: 4649–4653.

    Article  PubMed  CAS  Google Scholar 

  • Clayton, R.N., and Catt, K.H., 1981, Regulation of pituitary gonadotropin-releasing hormone receptors by gonadal hormones. Endocrinology, 108: 887–895.

    Article  PubMed  CAS  Google Scholar 

  • Corbani, M., Counis, R., Starzec, A., and Jutisz, M., 1984, Effect of gonadectomy on pituitary levels of mRNA encoding gonadotropin subunits and secretion of luteinizing hormone. Mol. Cell. Endocrinol., (in press).

    Google Scholar 

  • Counis, R., Corbani, M., Poissonnier, M., and Jutisz, M., 1982a, Characterization of the precursors of a ad subunits of follitropin following cell-free translation of rat and ovine pituitary mRNAs, Biochem. Biophys. Res. Chem. 107: 998–1005.

    Article  CAS  Google Scholar 

  • Counis, R., Corbani, M., Ribot, G., and Jutisz, M.,1982b, Cell-free synthesis of rat lutropin subunits, in “Hormonally active Brain Peptides: Structure and Function”, K.W. McKerns and V. Pantic, eds., pp. 567–579, Plenum Press, New York.

    Google Scholar 

  • Counis, R., Corbani, M., and Jutisz, M., 1982c, Studies on cell-free biosynthesis of lutropin (LH) and characterization of its subunit precursors, in: “Pituitary Hormones and Related Peptides”, M. Motta, M. Zanisi and F. Piva, eds., pp. 49–61, Academic Press, London and New York.

    Google Scholar 

  • Counis, R., Corbani, M., and Jutisz, M., 1983a, Régulation de la biosynthèse des gonadotropines hypophysaires, in “Multihormonal Regulations in Neuroendocrine Cells”, A. Tixier-Vidal and P. Richard, eds., pp. 509–523, INSERM, Paris (INSERM Symposium no 110, Colmar, France, 1–4 September 1982 ).

    Google Scholar 

  • Counis, R., Corbani, M., and Jutisz, M., 1983b, Estradiol regulates mRNAs encoding precursors to rat lutropin (LH) and follitropin ( FSH) subunits, Biochem. Biophys. Res. Commun., 114: 65–72.

    Article  PubMed  CAS  Google Scholar 

  • Davidson, J.M., 1969, Feedback control of gonadotropin secretion, in: “Frontiers in neuroendocrinology”, W.F. Ganong and L. Martini, eds., pp. 343–388, Oxford University Press, New York.

    Google Scholar 

  • Debeljuk, L., Khar, A., and Jutisz, M., 1978, Effects of gonadal steroids and cycloheximide on the release of gonadotrophins by rat pituitary cells in culture, J. End., 77: 409–415.

    Article  CAS  Google Scholar 

  • Everett, J.W., 1964, Central neural control of reproductive functions of the adenohypophysis, Physiol. Rev., 44: 373–431.

    PubMed  CAS  Google Scholar 

  • Fiddes, J.C., and Goodman, H.M., 1979, Isolation, cloning and sequence analysis of the cDNA for the a-subunit of human chorionic gonadotropin, Nature, 281: 351–356.

    Article  PubMed  CAS  Google Scholar 

  • Fiddes, J.C., and Goodman, H.M., 1980, The cDNA for the ß-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3’-untranslated region, Nature, 286: 684–687.

    Article  PubMed  CAS  Google Scholar 

  • Frager, M.S., Pieper, D.R., Tonetta, A., Duncan, J.A., and Marshall, J.C., 1981, Pituitary gonadotropin-releasing hormone receptors: Effects of castration, steroid replacement, and the role of gonadotropin-releasing hormone in modulating receptors in the rat. J. Clin. Invest., 67: 615–623.

    Article  PubMed  CAS  Google Scholar 

  • Gay, V.L., and Midgley, A.R., 1969, Response of the adult rat to orchidectomy and ovarieetomy as determined by LH radio-immunoassay, Endocrinology, 84: 1359–1364.

    Article  PubMed  CAS  Google Scholar 

  • Godine, J.E., Chin, W.W., and Habener, J.F., 1982, a subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs, J. Biol. Chem., 257: 8368–8371.

    PubMed  CAS  Google Scholar 

  • Jutisz, M., Counis, R., and Corbani, M., 1983, Biosynthesis of pituitary gonadotropins and its regulation by gonadoliberin (GnRH) and estradiol, in “Regulation of target cell responsiveness”, K.W. McKerns, ed., Plenum Press, New York, (in press).

    Google Scholar 

  • Khar, A., Debeljuk, L., and Jutisz, M., 1978, Biosynthesis of gonadotropins by rat pituitary cells in culture and in pituitary homogenates: Effect of gonadotropin-releasing hormone, Mol. Cell. Endocrinol., 12: 53–65.

    Article  PubMed  CAS  Google Scholar 

  • Landefeld, T.D., Kepa, J, and Karsch, F.J., 1983, Regulation of a subunit synthesis by gonadal steroid feedback in the sheep

    Google Scholar 

  • Lisk, R.D., and Newlon, M.,1963, Estradiol: evidence for its direct effect on hypothalamic neurons, Science, 139: 223–224.

    Article  PubMed  CAS  Google Scholar 

  • McCann, S.M., and Ramirez, V.D., 1964, The neuroendocrine regulation of hypophyseal luteinizing hormone secretion. Rec. Progr. Hormone Res., 20: 131–181.

    CAS  Google Scholar 

  • Nilson, J.H., Thomason, A.R., Cserbak, M.T., Moncman, C.L., and Woychik, R.P., 1983, Nucleotide sequence of cDNA for the common a subunit of the bovine pituitary glycoprotein hormones, J. Biol. Chem., 258: 4679–4682.

    PubMed  CAS  Google Scholar 

  • Pierce, J.G., and Parsons, T.F., 1981, Glycoprotein hormones: structure and function, Ann. Rev. Biochem. 50: 465–495.

    Article  PubMed  CAS  Google Scholar 

  • Schally, A.V., Kastin, A.J., and Arimura, A., 1972a, FSHreleasing hormone and LH-releasing hormone, Vitamins and Hormones, 30: 83–164.

    Article  PubMed  CAS  Google Scholar 

  • Schally, A.V., Redding, T.W., Matsuo, H., and Arimura, A., 1972b, Stimulation of FSH and LH release in vitro by natural and synthetic LH and FSH releasing hormone, Endocrinology 90: 1561–1568.

    Article  PubMed  CAS  Google Scholar 

  • Wallace, R.B., Shaffer, J., Murphy, R.F., Bonner, J., Hirose, T., and Itakura, K., 1979, Hybridization of synthetic oligodeoxynucleotides to 4X 174 DNA: The effect of single base pair mismatch, Nucleic Acids Res., 6: 3543–3557.

    Article  PubMed  CAS  Google Scholar 

  • Wallace, R.B., Johnson, M.J., Hirose, T., Miyake, T., Kawashima, E.H., and Itakura, K., 1981, The use of synthetic oligo nucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit ß-globin DNA, Nucleic Acids Res., 9: 879–894.

    Article  PubMed  CAS  Google Scholar 

  • Wheaton, J.E., and McCann, S.M., 1976, Luteinizing hormone-releasing hormone in peripheral plasma and hypothalamus of normal and ovariectomized rats, Neuroendocrinology 20: 296–310.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, M., Diebel, N.D., and Bogdanove, E.M., 1970, Analysis of initial and delayed effects of orchidectomy and ovariectomy on pituitary and serum LH levels in adult and immature rats, Endocrinology, 86: 1102–1111.

    Article  PubMed  CAS  Google Scholar 

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© 1984 Springer Science+Business Media New York

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Counis, R., Corbani, M., Jutisz, M. (1984). In Vivo Regulation by Estradiol of the Messenger RNAs Encoding LH and FSH Subunits and the Secretion of Gonadotropins. In: McKerns, K.W., Naor, Z. (eds) Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9960-5_27

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  • DOI: https://doi.org/10.1007/978-1-4684-9960-5_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9962-9

  • Online ISBN: 978-1-4684-9960-5

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