Abstract
Regression of the corpus luteum with the consequent loss of ovarian progesterone secretion appears to be an induced response which is necessary for the re-occurrence of ovulation. Conversely, prevention of corpus luteum regression is essential for the continuation of pregnancy. The pivotal role of the corpus luteum in the reproductive cycle with its poorly understood functional regulation and control has generated interest in this organ for many years. Although progress has been made, the nature, origin and mechanism of action of agents which prolong corpus luteum function during early pregnancy have not been resolved. Moreover, the nature, origin and mechanism of action of luteolytic hormones are poorly understood in lower animals, and are completely unknown in the human. It is to these areas that we have directed our attention.
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Behrman, H.R., Albert, P.J., Gore, S.D., Dorflinger, L.J. (1984). Calcium: A Cellular Mediator of Luteolysis. In: McKerns, K.W., Naor, Z. (eds) Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9960-5_18
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