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Centrally Mediated Cardiovascular Effects of Taurine

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Central Neural Mechanisms in Cardiovascular Regulation

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Abstract

Taurine, which is synthesized from methionine in vivo, is a sulfur amino acid widely distributed in mammalian tissues, especially in brain, heart, and skeletal muscle. Taurine has been extensively studied for its cardiovascular actions. In stroke-prone spontaneously hypertensive rats (SHRSP) (Nara et al., 1978), spontaneously hypertensive rats (SHR) (Abe et al., 1987), and deoxycorticosterone acetate (DOCA)-salt hypertensive rats (Fujita and Sato, 1986; Inoue et al., 1988), the administration of taurine could attenuate the development of hypertension (Fig. 5.1). The antihypertensive effect of taurine is most pronounced in a salt-induced hypertensive model associated with increased sympathetic activity (Bouvier and de Champlain, 1986; Sato et al., 1991), such as the DOCA-salt rat (Fujita and Sato, 1986; Inoue et al., 1988). In addition, taurine has other cardiovascular actions, such as negative inotropic and positive chronotropic effects on heart (Huxtable and Sebring, 1982).

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Authors
  1. Katsuyuki Ando
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  2. Toshiro Fujita
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Editor information

Editors and Affiliations

  1. Laboratory of Physiology and Pharmacologic Studies, NIAAA, Rockville, Maryland, 20852, USA

    George Kunos

  2. Department of Physiology, University of Western Ontario, Health Science Centre, London, Ontario, Canada, N6A 5C1

    John Ciriello

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© 1992 Birkhäuser Boston

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Ando, K., Fujita, T. (1992). Centrally Mediated Cardiovascular Effects of Taurine. In: Kunos, G., Ciriello, J. (eds) Central Neural Mechanisms in Cardiovascular Regulation. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-9184-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-9184-5_5

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-9186-9

  • Online ISBN: 978-1-4684-9184-5

  • eBook Packages: Springer Book Archive

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