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Baroreflexes in Hypertension

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Book cover Central Neural Mechanisms in Cardiovascular Regulation

Abstract

This chapter considers the effects of hypertension on the properties of baroreceptor-mediated sympathetic constrictor and heart rate reflexes in intact animals and humans, and some of the mechanisms that bring about these changes. The term “baroreceptor reflex” is often used with the implicit assumption that the arterial baroreceptors are either the sole, or by far the most, important afferent input. However, in the intact animal, all reflexes elicited through arterial pressure changes are compound reflexes, in which the afferent drive comes from arterial and several groups of nonarterial baroreceptors. This is because in intact animals changes in arterial pressure are always accompanied by alterations in pressure in other circulatory regions, including the heart chambers and pulmonary circulation (Guyton, 1963). The cardiopulmonary region is the source of the most important nonarterial pressure-sensitive receptors (Paintal, 1973; Thorén, 1979; Coleridge and Coleridge, 1980; Thorén, 1986). Some of these receptors play a role in baroreflex responses of normal animals, whereas others are important determinants of the characteristic changes in the reflex properties in chronic hypertension.

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Authors
  1. Paul I. Korner
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  2. Geoffrey A. Head
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Editor information

Editors and Affiliations

  1. Laboratory of Physiology and Pharmacologic Studies, NIAAA, Rockville, Maryland, 20852, USA

    George Kunos

  2. Department of Physiology, University of Western Ontario, Health Science Centre, London, Ontario, Canada, N6A 5C1

    John Ciriello

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© 1992 Birkhäuser Boston

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Korner, P.I., Head, G.A. (1992). Baroreflexes in Hypertension. In: Kunos, G., Ciriello, J. (eds) Central Neural Mechanisms in Cardiovascular Regulation. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-9184-5_15

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  • DOI: https://doi.org/10.1007/978-1-4684-9184-5_15

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-9186-9

  • Online ISBN: 978-1-4684-9184-5

  • eBook Packages: Springer Book Archive

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