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GABAB Receptors in the Nucleus Tractus Solitarius in Cardiovascular Regulation

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Central Neural Mechanisms in Cardiovascular Regulation

Abstract

The nucleus tractus solitarius (NTS), the site of termination of primary baroreceptor afferent nerves (Kalia and Sullivan, 1982; Kalia, 1981), plays a role in cardiovascular regulation (Spyer, 1990). Many neuroactive substances have been shown to be present in the NTS, many of which have been shown to play some role in the regulation of arterial blood pressure (AP) (Leslie, 1985; Talman et al, 1984). Still, the manner in which any specific neurotransmitter in the NTS acts physiologically in the regulation of AP has not been clearly elucidated. This chapter reviews the evidence that GABA, by acting on GABAB receptors in the NTS, contributes to the regulation of AP by modulating the baroreceptor reflex.

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Authors
  1. Alan F. Sved
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  2. Kazuyoshi Tsukamoto
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  3. Judith C. Sved
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Editors and Affiliations

  1. Laboratory of Physiology and Pharmacologic Studies, NIAAA, Rockville, Maryland, 20852, USA

    George Kunos

  2. Department of Physiology, University of Western Ontario, Health Science Centre, London, Ontario, Canada, N6A 5C1

    John Ciriello

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Sved, A.F., Tsukamoto, K., Sved, J.C. (1992). GABAB Receptors in the Nucleus Tractus Solitarius in Cardiovascular Regulation. In: Kunos, G., Ciriello, J. (eds) Central Neural Mechanisms in Cardiovascular Regulation. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-9184-5_14

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  • DOI: https://doi.org/10.1007/978-1-4684-9184-5_14

  • Publisher Name: Birkhäuser Boston

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