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Distribution and Functional Properties of PNA+ and PNA- Cells in Central and Peripheral Lymphoid Organs of the Chicken

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In Vivo Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 149))

Abstract

Peanut agglutinin (PNA) has turned out to be a potent tool to distinguish between cortical and medullary lymphocytes in the mouse thymus (1,2). In addition, more recent studies revealed that PNA may preferentially bind to cells acting as suppressors. PNA+ suppressor cells were detected in the fetal liver (3) and aging mouse spleen (4), as well as in the thymus of young adult animals (5). Furthermore, antigen-specific suppressors in the adult spleen were also characterized as PNA+ (6,7). Whereas the thymic and the antigen-specific splenic suppressor cells have been identified as T cells, the embryonic ones, and those appearing in aging were not eliminated by anti Thy 1.2 antibodies and complement (7 and unpublished observations). Hence, PNA seems to bind to suppressor cells of various membrane phenotypes. The possibility that PNA may enable identification and separation of various types of suppressor cells within the different lymphoid cell compartments thus seemed intriguing.

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References

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Author information

Author notes

  1. K. Schauenstein

    Present address: Institute for General and Experimental Pathology, University of Innsbruck, Austria

Authors and Affiliations

  1. Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel

    K. Schauenstein & A. Globerson

  2. Department of Biophysics, The Weizmann Institute of Science, Rehovot, 76100, Israel

    M. Rosenberg & N. Sharon

Authors
  1. K. Schauenstein
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  2. M. Rosenberg
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  3. A. Globerson
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  4. N. Sharon
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Editor information

Editors and Affiliations

  1. University of Groningen, Groningen, The Netherlands

    Paul Nieuwenhuis  & A. A. van den Broek  & 

  2. NCI-Frederick Cancer Research Facility, Frederick, Maryland, USA

    M. G. Hanna Jr.

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© 1982 Plenum Press, New York

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Schauenstein, K., Rosenberg, M., Globerson, A., Sharon, N. (1982). Distribution and Functional Properties of PNA+ and PNA- Cells in Central and Peripheral Lymphoid Organs of the Chicken. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_6

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  • DOI: https://doi.org/10.1007/978-1-4684-9066-4_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9068-8

  • Online ISBN: 978-1-4684-9066-4

  • eBook Packages: Springer Book Archive

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