Abstract
The thymus is the preferred site of amplification of the T cell compartment (1). This process is selective in that cytotoxic T cells, for example, recognize antigen preferentially in the context of the histocompatibility antigens expressed by thymus in which they differentiated and they require I-region compatible cooperating lymphohematopoietic cells for full expression of function (2). It appears that the preference for the non-I-region histocompatibility phenotype impressed by the thymus is a consequence of an interaction with radioresistant fixed cells of the thymus (2), probably epithelium, whereas the cooperating I-region requirement is imposed by immigrant thymic antigen-presenting cells (APC) (3).
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Dappen, G.E., Crouse, D.A., Anderson, R.W., Jordan, R.K., Robinson, J.H., Sharp, J.G. (1982). Morphological Assessment of Immunologically Relevant Cells in the Thymus. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_54
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DOI: https://doi.org/10.1007/978-1-4684-9066-4_54
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