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Accumulation of Mature T and B Cells and Abnormalities of Lymphocyte Traffic in the Thymus of Aged NZB × SJL F1 Female Mice

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In Vivo Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 149))

Abstract

NZB × SJL F1 female (NSF) mice develop a dramatic hypertrophy of the thymus during aging, which provides a unique model of sex-dependent thymic pathology (1). The present report summarizes a series of studies intended at examining the significance of this phenomenon. In order to determine the cellular events underlying the thymic hypertrophy, we combined histological observations by light and electron microscopy with the phenotypic characterization of dissociated thymic cells using flow cytofluorometry (FCF) (2). Furthermore, we undertook homing experiments with radioactively labeled cells as an attempt to investigate the possibility that abnormalities of lymphocyte ecotaxis (3) might be associated with the aberrant behavior of the NSF thymus.

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References

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Author information

Authors and Affiliations

  1. Dept. of Immunology, Merck Sharp & Dohme Research Laboratories, Rahway, NJ, 07065, USA

    Francis Dumont, Robert C. Habbersett, Roger Barrois & Hubert Gerard

  2. Unit of Experimental Cancerology, INSERM U95 and Dept. of Histology, Faculty of Medicine, Vandoeuvre-les-Nancy, 54500, France

    Francis Dumont, Robert C. Habbersett, Roger Barrois & Hubert Gerard

Authors
  1. Francis Dumont
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  2. Robert C. Habbersett
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  3. Roger Barrois
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  4. Hubert Gerard
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Editor information

Editors and Affiliations

  1. University of Groningen, Groningen, The Netherlands

    Paul Nieuwenhuis  & A. A. van den Broek  & 

  2. NCI-Frederick Cancer Research Facility, Frederick, Maryland, USA

    M. G. Hanna Jr.

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© 1982 Plenum Press, New York

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Dumont, F., Habbersett, R.C., Barrois, R., Gerard, H. (1982). Accumulation of Mature T and B Cells and Abnormalities of Lymphocyte Traffic in the Thymus of Aged NZB × SJL F1 Female Mice. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_41

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  • DOI: https://doi.org/10.1007/978-1-4684-9066-4_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9068-8

  • Online ISBN: 978-1-4684-9066-4

  • eBook Packages: Springer Book Archive

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