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Modern Phytochemical Methods pp 371–396Cite as

Quantitative Structure-Activity Relationship Analysis of Natural Products: Phototoxic Thiophenes

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Part of the book series: Recent Advances in Phytochemistry ((RAPT,volume 25))

Abstract

The wide diversity of secondary metabolites known to exist throughout the plant kingdom has been partially attributed to plant-pest coevolution,1,2 although aspects of the process remain controversial.3 It is also known that fungal infections can elicit the production and accumulation of toxic plant secondary metabolites.4 The elaborate design of chemical defences in plants can involve mixtures of related structures in one biosynthetic class or multiple lines of chemical defence in a single plant species.5 For example, Chrysanthemum spp. contain several phototoxic thiophenes and acetylenes, cytotoxic sesquiterpene lactones, and insecticidal Pyrethrins and isobutylamides.6

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Authors and Affiliations

  1. Ottawa-Carleton Institute of Biology, University of Ottawa, Ottawa, Ontario, Canada, K1N 6N5

    Robin J. Marles & J. Thor Arnason

  2. Department of Biopharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA

    R. Lilia Compadre & Cesar M. Compadre

  3. Ottawa-Carleton Institute of Chemistry, University of Ottawa, Ottawa, Ontario, Canada, K1N 6N5

    Chantal Soucy-Breau, Bella Mehta & Peter Morand

  4. Steacie Institute for Molecular Sciences, National Research Council, Ottawa, Ontario, Canada, K1A 0R6

    Robert W. Redmond & J. C. Scaiano

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  1. Robin J. Marles
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  2. J. Thor Arnason
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  6. Bella Mehta
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Editor information

Editors and Affiliations

  1. Louisiana State University, Baton Rouge, Louisiana, USA

    Nikolaus H. Fischer

  2. University of British Columbia, Vancouver, British Columbia, Canada

    Murray B. Isman

  3. Reed College, Portland, Oregon, USA

    Helen A. Stafford

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© 1991 Plenum Press, New York

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Marles, R.J. et al. (1991). Quantitative Structure-Activity Relationship Analysis of Natural Products: Phototoxic Thiophenes. In: Fischer, N.H., Isman, M.B., Stafford, H.A. (eds) Modern Phytochemical Methods. Recent Advances in Phytochemistry, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9060-2_11

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