Skip to main content
SpringerLink
Log in

New Developments in the Separation of Natural Products

  • Chapter
Modern Phytochemical Methods

Part of the book series: Recent Advances in Phytochemistry ((RAPT,volume 25))

  • 269 Accesses

Abstract

Over the last ten years, there has been a growing interest in drugs of plant origin. During this period, consumption of medicinal plants has almost doubled in industrialized countries of Western Europe where substances derived from higher plants constitute approximately 25% of prescribed medicines.1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. PRINCIPE, P.P. 1989. The economic significance of plants and their constituents as drugs. In: Economic and Medicinal Plant Research 3 (H. Wagner, H. Hikino, and N. Farnsworth, eds.), Academic Press, London, pp. 1–17.

    Google Scholar 

  2. HOSTETTMANN, K. 1987. Recherches actuelles dans le domaine des plantes médicinales. Bull. Soc. Frib. Sc. Nat. 76: 51–63.

    Google Scholar 

  3. HOSTETTMANN, K., HOSTETTMANN, M., MARSTON, A. 1986. Preparative Chromatography Techniques: Applications in Natural Product Isolation. Springer Verlag, Berlin, pp. 139.

    Google Scholar 

  4. HOSTETTMANN, K. 1983. Droplet countercurrent chromatography. In: Advances in Chromatography. Vol. 21. (J.C. Giddings, E. Grus-chka, J. Cazes, P.R. Brown, eds.), Marcel Dekker, New York, pp 165–185.

    Google Scholar 

  5. MARSTON, A., SLACANIN, I., HOSTETTMANN, K. 1990. Centrifugal partition chromatography in the separation of natural products. Phytochemical Analysis, in press.

    Google Scholar 

  6. TARGETT, N.M., KILCOYNE, J.P., GREEN, B. 1979. Vacuum liquid chromatography. An alternative to common chromatographic methods. J. Org. Chem. 44: 4962–4964.

    Article  CAS  Google Scholar 

  7. STILL, W.C., KAHN, M., MITRA, A. 1978. Rapid chromatographic technique for preparative separations with moderate resolution. J. Org. Chem. 43: 2923–2925.

    Article  CAS  Google Scholar 

  8. DECOSTERD, L.A., DORSAZ, A.-C., HOSTETTMANN, K. 1987. Application of semi-preparative high-performance liquid chromatography to difficult natural product separations. J. Chromatogr. 406: 367–373.

    Article  PubMed  CAS  Google Scholar 

  9. HOSTETTMANN, K., HOSTETTMANN-KALDAS, M., STICHER, O. 1980. Rapid preparative separation of natural products by centrifugal thin-layer chromatography. J. Chromatogr. 202: 154–156.

    Article  CAS  Google Scholar 

  10. MANDAVA, N.B., ITO, Y. 1988. Countercurrent Chromatography: Theory and Practice. Marcel Dekker, New York, pp. 841

    Google Scholar 

  11. HOSTETTMANN, K., MARSTON, A. 1990. Liquid-liquid partition chromatography in natural product isolation. Analytica Chimica Acta, in press.

    Google Scholar 

  12. ITO, Y., BOWMAN, R.L. 1970. Countercurrent chromatography: Liquid-liquid partition chromatography without solid support. J. Chromatogr. Sci. 8: 315–323.

    CAS  Google Scholar 

  13. SNYDER, J.K., NAKANISHI, K., HOSTETTMANN, K., HOSTETTMANN, M. 1984. Applications of rotation locular countercurrent chromatography in natural products isolation. J. Liquid Chromatogr. 7: 243–256.

    Article  CAS  Google Scholar 

  14. TANIMURA, T., PISANO, J.J., ITO, Y., BOWMAN, R.L. 1970. Droplet countercurrent chromatography. Science 169: 54–56.

    Article  PubMed  CAS  Google Scholar 

  15. HOSTETTMANN, K. 1980. Droplet countercurrent chromatography and its application to the preparative scale separation of natural products. Planta Med. 39: 1–18.

    Article  CAS  Google Scholar 

  16. DOMON, B., HOSTETTMANN, M., HOSTETTMANN, K. 1982. Droplet countercurrent chromatography with non-aqueous solvent systems. J. Chromatogr. 246: 133–135.

    Article  CAS  Google Scholar 

  17. ITO, Y. 1981. Countercurrent chromatography. J. Biochem. Biophys. Methods 5: 105–129.

    Article  PubMed  CAS  Google Scholar 

  18. ITO, Y. 1986. High-speed countercurrent chromatography. Crit. Rev. Anal. Chem. 17: 65–143.

    Article  CAS  Google Scholar 

  19. MURAYAMA, W., KOBAYASHI, T., KOSUGE, Y., YANO, H., NUNO-GAKI, Y., NUNOGAKI, K. 1982. A new centrifugal countercurrent Chromatograph and its application. J. Chromatogr. 239: 643–649.

    Article  CAS  Google Scholar 

  20. BERTHOD, A., ARMSTRONG, D.W. 1988. Centrifugal partition chromatography I. General features. J. Liquid Chromatogr. 11: 547–583.

    Article  CAS  Google Scholar 

  21. ITO, Y., SANDLIN, J., BOWERS, W.G. 1982. High-speed preparative countercurrent chromatography with a coil planet centrifuge. J. Chromatogr. 244: 247–258.

    Article  CAS  Google Scholar 

  22. ITO, Y. 1984. Experimental observations of the hydrodynamic behaviour of solvent systems in high-speed countercurrent chromatography. Part I. Hydrodynamic distribution of two solvent phases in a helical column subjected to two types of synchronous planetary motion. J. Chromatogr. 301: 377–386.

    Article  PubMed  CAS  Google Scholar 

  23. ITO, Y., CHOU, F.E. 1988. New high-speed countercurrent Chromatograph equipped with a pair of separation columns connected in series. J. Chromatogr. 454: 382–386.

    Article  PubMed  CAS  Google Scholar 

  24. ITO, Y., OKA, H., SLEMP, J.L. 1989. Improved high-speed countercurrent Chromatograph with three multilayer coils connected in series. I. Design of the apparatus and performance of semi-preparative columns in 2,4-dinitrophenyl amino acid separation. J. Chromatogr. 475: 219–227.

    Article  PubMed  CAS  Google Scholar 

  25. OKUDA, T., YOSHIDA, T., HATANO, T., YAZAKI, K., KIRA, R., IKEDA, Y. 1986. Chromatography of tannins II. Preparative fractionation of hydrolyzable tannins by centrifugal partition chromatography. J. Chromatogr. 362:375–381.

    Article  CAS  Google Scholar 

  26. CONWAY, W.D., ITO, Y. 1984. Evaluation of non-aqueous solvent systems for countercurrent chromatography using an HPLC assay to determine partition coefficients of a mixture of compounds. J. Liquid Chromatogr. 7:291–302.

    Article  CAS  Google Scholar 

  27. MARSTON, A., BOREL, C., HOSTETTMANN, K. 1988. Separation of natural products by centrifugal partition chromatography. J. Chromatogr. 450:91–99.

    Article  CAS  Google Scholar 

  28. SLACANIN, I., MARSTON, A., HOSTETTMANN, K. 1989. Modifications to a high-speed countercurrent Chromatograph for improved separation capability. J. Chromatogr. 482: 234–239.

    Article  CAS  Google Scholar 

  29. MARSTON, A., CHAPUIS, J.-C., SORDAT, B., MSONTHI, J.D., HOSTETTMANN, K. 1986. Anthracenic derivatives from Psoro-spermum febrifugum and their in vitro cytotoxicities to a human colon carcinoma cell line. Planta Medica 52: 207–210.

    Article  Google Scholar 

  30. ZHANG, T.-Y., HUA, X., XIAO, R., KONG, S. 1988. Separation of flavonoids in crude extracts from sea buckthorn by countercurrent chromatography with two types of coil planet centrifuge. J. Liq. Chromatogr. 11: 233–244.

    Article  CAS  Google Scholar 

  31. THOMAS-BARBERAN, F.A., HOSTETTMANN, K. 1988. A cytotoxic triterpenoid and flavonoids from Crossopteryx febrífuga. Planta Medica 54: 266–267.

    Article  Google Scholar 

  32. VANHAELEN, M., VANHAELEN-FASTRE, R. 1988. Countercurrent chromatography for isolation of flavonol glycosides from Ginkgo biloba leaves. J. Liq. Chromatogr. 11: 2969–2975.

    Article  CAS  Google Scholar 

  33. OKUDA, T., YOSHIDA, T., HATANO, T. 1988. Application of centrifugal partition chromatography to tannins and related polyphenols. J. Liq. Chromatogr. 11: 2447–2454.

    Article  CAS  Google Scholar 

  34. YOSHIDA, T., CHEN, X.-M., HATANO, T., FUKUSHIMA, M., OKUDA, T. 1987. Tannins and related polyphenols from rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburgii fruits. Chem. Pharm. Bull. 35: 1817–1822.

    Article  PubMed  CAS  Google Scholar 

  35. PUTMAN, L.J., BUTLER, L.G. 1985. Fractionation of condensed tannins by countercurrent chromatography. J. Chromatogr. 318: 85–93.

    Article  CAS  Google Scholar 

  36. MARSTON, A., HOSTETTMANN, K. 1988. Application of centrifugal countercurrent chromatography in the separation of natural products. Planta Medica 54: 558.

    Article  PubMed  CAS  Google Scholar 

  37. VAN WAGENEN, B.C., HUDDLESTON, J., CARDELLINA, J.H. 1988. Native American food and medicinal plants. 8. Water-soluble constituents of Lomatium dissectum. J. Nat. Prod. 51: 136–141.

    Article  Google Scholar 

  38. PETTIT, G.R. AND SCHAUFELBERGER, D.E. 1988. Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A. J. Nat. Prod. 51: 1104–112.

    Article  PubMed  CAS  Google Scholar 

  39. DECOSTERD, L.A. 1990. Isolement et détermination de structure de constituants biologiquement actifs de deux espèces de la famille des Guttifères: Hypericum revolutum Vahl et Hypericum calycinum L. Ph.D. Thesis, University of Lausanne.

    Google Scholar 

  40. YANG, Y.M., LLOYD, H.A., PANNELL, L.K., FALES, H.M., MACFARLANE, R.D., MCEAL, C.J., ITO, Y. 1986. Separation of the components of commercial digitonin using high-performance liquid chromatography and centrifugal countercurrent chromatography. Identification of the products by Californium-252 plasma desorption mass spectrometry. Biomed. Environ. Mass Spectrom. 13: 439–445.

    Article  PubMed  CAS  Google Scholar 

  41. BRUENING, R.C., DERGUINI, F., NAKANISHI, K. 1986. Preparative scale isolation of 11-cis-retinal from isomeric retinal mixture by centrifugal partition chromatography. J. Chromatogr. 357: 340–343.

    Article  PubMed  CAS  Google Scholar 

  42. DIALLO, B., VANHAELEN, M. 1988. Large scale purification of apocarotenoids from Cochlospermum tinctorium by countercurrent chromatography. J. Liq. Chromatogr. 11: 227–231.

    Article  CAS  Google Scholar 

  43. ACTON, N., KLAYMAN, D.L., ROLLMAN, I.J., Novotny, J.F. 1986. Isolation of artemisinin (qinghaosu) and its separation from artemisinene using the Ito multilayer coil separator-extractor and isolation of arteannuin. B. J. Chromatogr. 355: 448–450.

    CAS  Google Scholar 

  44. VARGAS, D., DOMINGUEZ, X.A., ACUNA-ASKAR, K., GUTIERREZ, M., HOSTETTMANN, K. 1988. Norditerpenes and norditerpene glycosides from Drymaria arenarioides. Phytochemistry 27: 1532–1534.

    Article  CAS  Google Scholar 

  45. QUETIN-LECLERCQ, J., ANGENOT, L., DUPONT, L., BISSET, N.G. 1988. Isolation and purification of panarine, an alkaloid from a Venezuelan curare. Phytochemistry 27: 4002–4004.

    Article  CAS  Google Scholar 

  46. QUETIN-LECLERCQ, J., ANGENOT, L. 1988. 10-Hydroxy N-methyl-coryantheol, a new quaternary alkaloid from the stem bark of Strychnos usambarensis. Phytochemistry 27: 1923–1926.

    Article  CAS  Google Scholar 

  47. KANYINDA, B., DIALLO, B., VANHAELEN-FASTRE, R., VANHAELEN, M. 1989. Benzylisoquinoline alkaloids from Anisocycla cymosa roots. Planta Medica 55: 394.

    Article  PubMed  CAS  Google Scholar 

  48. ZHANG, T.-Y., CAI, D.-G., ITO, Y. 1988. Separations of flavonoids and alkaloids in medicinal herbs by high-speed countercurrent chromatography. J. Chromatogr. 435: 159–166.

    Article  PubMed  CAS  Google Scholar 

  49. MARSTON, A., ZAGORSKI, M.G., HOSTETTMANN, K. 1988. Antifungal Polyphenols from Cordia goetzei. Gürke. Helv. Chim. Acta 71: 1210–1219.

    Article  CAS  Google Scholar 

  50. DECOSTERD, L.A., STOECKLI-EVANS, H., MSONTHI, J.D., HOSTETTMANN, K. 1987. New antifungal chromenyl ketones and their pentacyclic dimers from Hypericum revolutum. Vahl. Helv. Chim. Acta 70: 1694–1702.

    Article  CAS  Google Scholar 

  51. DECOSTERD, L.A., STOECKLI-EVANS, H., CHAPUIS, J.C., MSONTHI, J.D., SORDAT, B., HOSTETTMANN, K. 1989. New hyperforin derivatives from Hypericum revolutum Vahl with growth-inhibitory activity against a human colon carcinoma cell line. Helv. Chim. Acta 72: 464–472.

    Article  CAS  Google Scholar 

  52. FARNSWORTH, N.R., KINGHORN, A.D., SOEJARTO, D.D., WALLER, D.P. 1985. Siberian ginseng (Eleutherococcus senti-cosus): Current status as an adaptogen. In: Economic and medicinal plant research. I., (H. Wagner, H. Hikino, N.R. Farnsworth, eds.), Academic Press, London, pp 155–215.

    Google Scholar 

  53. SLACANIN, I., MARSTON, A., GUEDON, D., HOSTETTMANN, K. 1990. The separation of Eleutherococcus senticosus constituents and their quantitative analysis by HPLC. Phytochemical Analysis, in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmacognosy and Phytochemistry, School of Pharmacy, University of Lausanne, CH-1005, Lausanne, Switzerland

    Kurt Hostettmann, Matthias Hamburger, Maryse Hostettmann & Andrew Marston

Authors
  1. Kurt Hostettmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Matthias Hamburger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maryse Hostettmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrew Marston
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Louisiana State University, Baton Rouge, Louisiana, USA

    Nikolaus H. Fischer

  2. University of British Columbia, Vancouver, British Columbia, Canada

    Murray B. Isman

  3. Reed College, Portland, Oregon, USA

    Helen A. Stafford

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Hostettmann, K., Hamburger, M., Hostettmann, M., Marston, A. (1991). New Developments in the Separation of Natural Products. In: Fischer, N.H., Isman, M.B., Stafford, H.A. (eds) Modern Phytochemical Methods. Recent Advances in Phytochemistry, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9060-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-9060-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9062-6

  • Online ISBN: 978-1-4684-9060-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation