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Position-Dependent Growth Control and Pattern Formation in Limb Regeneration

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Book cover Recent Trends in Regeneration Research

Part of the book series: NATO ASI Series ((NSSA,volume 172))

Abstract

Results from experimental studies in regenerating and developing amphibian limbs have led us to conclude that growth and pattern formation are coordinately controlled (French et al., 1976; Bryant et al., 1981; Bryant et al., 1987). This conclusion is based on two propositions: (1) cells possess information about their position in the limb (i.e. cells have positional values); and (2) whenever discontinuities exist in the array of positional values, interactions between adjacent cells with different positional values will result in the stimulation of growth and in the intercalation of appropriate intervening positional values. Consequently, growth will cease when all positional disparities have been resolved. As we discuss below, cellular interactions resulting in the stimulation of growth can occur during normal development as a result of cell rearrangements within the limb field, during regeneration as a result of cell migration associated with wound healing, or in experimental situations as a result of grafting to bring cells with disparate positional properties (e.g. anterior and posterior) into contact. Hence, this view can account for the initiation, maintenance and termination of limb growth and patterning during normal development, after amputation, as well as after a variety of experimental manipulations.

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Authors and Affiliations

  1. Developmental Biology Center, University of California, Irvine, Irvine, California, 92717, USA

    Susan V. Bryant & David M. Gardiner

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  1. Susan V. Bryant
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  2. David M. Gardiner
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Editors and Affiliations

  1. University of Athens, Athens, Greece

    V. Kiortsis  & S. Koussoulakos  & 

  2. University of Birmingham, Birmingham, UK

    H. Wallace

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© 1989 Plenum Press, New York

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Bryant, S.V., Gardiner, D.M. (1989). Position-Dependent Growth Control and Pattern Formation in Limb Regeneration. In: Kiortsis, V., Koussoulakos, S., Wallace, H. (eds) Recent Trends in Regeneration Research. NATO ASI Series, vol 172. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9057-2_36

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  • DOI: https://doi.org/10.1007/978-1-4684-9057-2_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9059-6

  • Online ISBN: 978-1-4684-9057-2

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