Summary
Evidence for the suggested role of the immune system in epimorphic regeneration was sought by assessing effects on regeneration of immunological agents or active cellular immunity (allograft rejection) and by comparing immunological expression (e.g. mitogen responsiveness of splenocytes and interleukin 2 distribution) during regeneration with that following nonamputational trauma. There appeared to be no significant participation of humoral immunity in either epimorphic regeneration or repair of nonamputational wounds. However, expression of cellular immunity during regeneration differed from that observed during repair of nonamputational wounds. Moreover, expression of cellular immunity following amputation appeared to affect the progress of regeneration. This suggests that the nature of wounds can modulate expression of cellular immunity which, in turn, can affect mechanisms of wound repair, e.g. epimorphic regeneration vs fibroplasia and fibrosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adair, L.C., and Taban, C.H., 1971, Comparison of wound healing and/or regeneration in mammals and urodeles, Arch. Sci. (Geneve), 24:499–516.
Brunst, V.V. and Cheremetieva, E.A., 1936, Sur la perte du pouvoir regenerateur chez le triton et l’axolotl par 1’irradiation avec les rayons X., Arch. Zool. Exp. (Geneve), 79:57–67.
Butler, E.G., 1935, Studies on limb regeneration in x-rayed Amblystoma larvae, Anat. Rec., 62:295–307.
Butler, E.G. and O’Brien, J.P., 1942, Effects of localized x-irradiation on regeneration of the urodele limb, Anat. Rec., 84:407–413.
Carrel, A., 1921, Cicatrization of wounds. XII. Factors initiating regeneration, J. Exp. Med., 34:425–434.
Carrel, A. 1922. Growth-promoting function of leukocytes, J. Exp. Med., 36:385–391.
Cohen, N., 1966, Tissue transplantation immunity in the adult newt, Diemictylus viridescens, J. Exp. Zool., 163:157–190.
Fritsch, C., 1911, Experimentelle Studien über Regenerationsvorgänger des Gleidmassenskeletts, Zool. Jahrb. Abt. Physiol., 30:377–472.
Hay, E.D., and Fischman, D.A., 1961, Origin of the blastema in regenerating limbs of the newt Triturus viridescens. An autoradiographic study using tritiated thymidine to follow cell proliferation and migration, Dev. Biol., 3:26–59.
Hellmich, W., 1930, Untersuchungen über Herkunft und Determination des Regenerativen Materials bei Amphibien, Wilhelm Roux’s Arch.. 121:135–202.
Hellmich, W., 1931, Histology of regeneration in different species of adult and larval urodeles, Anat. Rec., 48:303–307.
Hightower, J.A., and St. Pierre, R.L., 1971, Hemopoietic tissues of the adult newt, Notophthalmus viridescens, J. Morph.. 135:299–308.
Hightower, J.A. and St. Pierre, R.L., 1972, Skin allografts in the newt, Notophthalmus viridescens: cessation of blood flow as an indicator of rejection, J. Exp. Zool., 181:341–352.
Horton, J.D., Smith, A.R., Williams, N.H., Smith, A., and Sherif, N.E.H.S., 1980, Lymphocyte reactivity to “T” and “B” cell mitogens in Xenopus laevis; studies on thymus and spleen, Devel. Comp. Immunol., 4:75–86.
Ide-Rozas, A., 1937, Die Zytologische Verhältnisse bei der Regeneration von Kaulquappenextremitäten, Wilhelm Roux’s Arch., 135:552–608.
Liebman, E., 1946, On trephocytes and trephocytosis: a study of the role of leukocytes in nutrition and growth, Growth, 10:291–330.
Liebman, E., 1949. The leukocytes in regenerating limbs of Triturus viridescens. Growth, 13:103–118.
Oppenheim, J. and Landy, M., 1983, “Interleukins, Lymphokines, and Cytokines”, Academic Press, New York.
Oppenheim, J., Rosenstreich, D.L., and Potter, M., 1981, “Cellular Functions in Immunity and Inflammation”, Elsevier/North-Holland, New York.
Prehn, R.T., 1970, Immunosurveillance, regeneration, and oncogenesis, Procfr. Exp. Tumor Res., 14:1–24.
Prehn, R.T., 1971, Percpectives on oncogenesis: Does immunity stimulate or inhibit neoplasia? J. Reticuloendothel. Soc., 10:1–16.
Prehn, R.T., 1972, The immune reaction as a stimulator of tumor growth, Science, 176:170–171.
Prehn, R.T. and Lappe, M., 1971, An immunostimulation theory of tumor development, Transplant. Rev., 7:26–54.
Ross, R. , 1970, Wound healing, a review. in: “Chemistry and Molecular Biology of the Intercellular Matrix”. Vol. 3 E.A. Belasz, et al., eds. Academic Press, New York, pp. 1739–1751.
Schmidt, A.J., 1968, “Cellular Biology of Vertebrate Regeneration and Repair”, Univ. Chicago Press, Chicago.
Schotte, O.E. and Sicard, R.E., 1982, Cyclophosphamideinduced leukopenia and suppression of limb regeneration in the adult newt, Notophthalmus viridescens, J. Exp. Zool., 222:199–202.
Sicard, R.E., 1981a, The effects of putative immunological manipulations upon the rate of forelimb regeneration in adult newts, Notophthalmus viridescens, IRCS Med. Sci, . 9:962–963.
Sicard, R.E., 1981b, Morphologically aberrant limb regeneration in adult newts induced by putative immunological manipulations, IRCS Med. Sci., 9:964–965.
Sicard R.E., 1985, Leukocytic and immunological influence on regeneration of amphibian forelimbs. in: “Regulation of Vertebrate Limb Regeneration”, R.E. Sicard, ed., Oxford Univ. Press, New York, pp. 128–145.
Sicard, R.E. and Laffond, W.T., 1983, Putative immunological influence upon amphibian forelimb regeneration. I. Effects of several immunoactive agents on regeneration rate and gross morphology, Exp. Cell Biol.. 51:337–344.
Sipe, J.D., and Rosenstreich, D.L., 1981, Serum factors associated with inflammation. in: “Cellular Functions in Immunity and Inflammation”, J.J. Oppenheim, D.L. Rosenstreich, and M. Potter, eds., Elsevier/North Holland, New York.
Sorg, C. and Schimpi, A., 1985, “Cellular and Molecular Biology of Lymphokines”, Academic Press, New York.
Wahl, S.M., 1981. Inflammation and wound healing. in: “Cellular Functions in Immunity and Inflamination”, J.J. Oppenheim, D.L. Rosenstreich, and M. Potter, eds, Elsevier/North Holland, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Sicard, R.E., Lombard, M.F. (1989). Epimorphic Regeneration and the Immune System. In: Kiortsis, V., Koussoulakos, S., Wallace, H. (eds) Recent Trends in Regeneration Research. NATO ASI Series, vol 172. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9057-2_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-9057-2_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-9059-6
Online ISBN: 978-1-4684-9057-2
eBook Packages: Springer Book Archive