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Implication of Transglutaminase in Mitogen-Induced Human Lymphocyte Blast Transformation

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Advances in Post-Translational Modifications of Proteins and Aging

Part of the book series: Advances in Experimental Medicine and Biology ((NATO ASI F,volume 231))

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Abstract

Lymphocytes are unique cells evolved to guard, in collaboration with other accessory cells (such as macrophages), the selfness of vertebrate organisms against the invasiveness of alien elements or macromolecules. Recognition of intruders is obtained either by cell-cell or cell-molecule interactions, in which sophisticated biochemical machineries, endowed in the lymphocyte plasma membrane, are set in action as important parts of defence mechanisms used by singles to defend their own individualities. As a consequence of the activity of all these surface molecular devices, a metabolic turmoil is triggered in these cells. Numerous intra- and extra-cellular biochemical signals are released, bringing about in a short time marked modifications of a number of important metabolic pathways such as those related to: 1) energy production; 2) control of electrolyte traffic in the cell; 3) transcription and translation of specific messenger RNA; 4) biosynthesis of tRNA and rRNA; 5) control of DNA replication and cell division1–10.

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Author information

Authors and Affiliations

  1. CNR Inst. Prot. Biochem. Enzymol., Arco Felice, Naples, Italy

    S. Metafora & G. Peluso

  2. CNR Inst. Exptl. Medicine, Rome, Italy

    G. Ravagnan

  3. Inst. Chem. and Biol. Chem., 1st Med. School, Univ. of Naples, Naples, Italy

    A. Fusco, V. Gentile & R. Porta

Authors
  1. S. Metafora
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  2. G. Peluso
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  3. G. Ravagnan
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  4. A. Fusco
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  5. V. Gentile
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  6. R. Porta
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Editor information

Editors and Affiliations

  1. University of Naples, Naples, Italy

    Vincenzo Zappia , Patrizia Galletti  & Raffaele Porta ,  & 

  2. University of Texas Health Science Center, Houston, Texas, USA

    Finn Wold

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© 1988 Springer Science+Business Media New York

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Metafora, S., Peluso, G., Ravagnan, G., Fusco, A., Gentile, V., Porta, R. (1988). Implication of Transglutaminase in Mitogen-Induced Human Lymphocyte Blast Transformation. In: Zappia, V., Galletti, P., Porta, R., Wold, F. (eds) Advances in Post-Translational Modifications of Proteins and Aging. Advances in Experimental Medicine and Biology, vol 231. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9042-8_14

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  • DOI: https://doi.org/10.1007/978-1-4684-9042-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9044-2

  • Online ISBN: 978-1-4684-9042-8

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