Hormonal Influence on the Recirculation of Lymphocytes Through the Regional Lymph Node and Regional Tissues of the Sheep

Abstract

There is a large scale migration of lymphoid cells from the blood vascular system into lymphoid tissues and a return by way of the lymphatic system as described by Gowans and others (see reviews 1,2). Despite the magnitude of this recirculation process, as shown in Fig. 1, little is known of the factors controlling lymphocyte recirculation and, particularly, the action hormones may have on this process. With this aim in mind, the effects of relatively small doses of ACTH and hydrocortisone on the recirculation process at the level of the local lymph node and through peripheral tissues were investigated in the sheep. A more detailed report of earlier work in this area has been presented elsewhere (3).