Abstract
Unilamellar or multilamellar vesicles prepared from synthetic non-ionic surfactants can be considered to be synthetic surfactant analogues of liposomes (Baillie, 1988; Florence and Baillie, 1989). The exploration of alternatives to phospholipids as the main lipid moiety in the fabrication of vesicles is in itself worthwhile, particularly as phospholipid raw materials are naturally occurring substances, not always in plentiful supply, and may be unstable during storage and processing. Methods for the processing of lipid raw material, for synthesizing, modifying and purifying natural lipids, are important for the ultimate large-scale clinical use of phospholipid-based vesicular delivery. Moreover, by studying the behaviour of vesicles constructed from nonionic surfactants (or other lipid species) there is the potential to determine what are the key chemical and physical factors which control biological distribution and targeting.
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Florence, A.T., Cable, C., Cassidy, J., Kaye, S.B. (1990). Non-Ionic Surfactant Vesicles as Carriers of Doxorubicin. In: Gregoriadis, G., Allison, A.C., Poste, G. (eds) Targeting of Drugs 2. NATO ASI Series, vol 199. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-9001-5_11
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