Abstract
The thermotropic and lyotropic phase behavior of components that comprise lipid assemblies such as liposomes results in an inherent instability of these structures when exposed to extremes of temperature and hydration. This can present significant limitations to their successful application. As liposomes and other macroassemblies of lipid molecules progress toward application, considerable efforts have been made to improve the stability of these structures. We can define stabilization of lipid microstructures as the ability to withstand chemical, mechanical, or thermal extremes which may be encountered in the variety of applications that are being pursued. In particular, the definition of stabilization for drug delivery and slow release purposes should include increased persistence in the body and avoidance of the reticular endothelial system (RES) which will result in enhanced activity of encapsulants in vivo.
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Rudolph, A.S., Singh, A., Price, R.R., Goins, B., Gaber, B.P. (1990). Stabilization of Lipid Microstructures: Fundamentals and Applications. In: Gregoriadis, G., Allison, A.C., Poste, G. (eds) Targeting of Drugs 2. NATO ASI Series, vol 199. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-9001-5_10
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DOI: https://doi.org/10.1007/978-1-4684-9001-5_10
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