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The Analysis of Bordetella Pertussis Fimbrial Mutants in a Rabbit Model

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Microbial Surface Components and Toxins in Relation to Pathogenesis

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 51))

Abstract

Bordetella pertussis is the causative agent of whooping cough or pertussis, a serious respiratory disease (see ref. 1 for an excellent review). The first step in the pathogenesis of pertussis is adherence of the bacteria to the respiratory tract, and two classes of bacterial proteins are probably involved in this process, filamentous hemagglutinin (FHA), and fimbriae. After adherence, the bacteria proliferate and produce a number of toxins: tracheal cytotoxin, dermonecrotic toxin, adenyl cyclase and pertussis toxin. These toxins cause local tissue damage, immune suppression, and are responsible for the systemic effects of the disease. It has been suggested that pertussis toxin may also function as a colonization factor, since it is able to bind to both the bacteria and the host-cells (1).

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Author information

Authors and Affiliations

  1. Department of Bacteriology, National Institute of Health and Environmental Protection, PO Box 1, 3720 BA, Bilthoven, The Netherlands

    Frits R. Mooi, Han G. J. van der Heide, Henk C. Walvoort, Henk Brunings, Wim H. Jansen & Piet A. M. Guinee

  2. Department of Control of Bacterial Vaccines, National Institute of Health and Environmental Protection, PO Box 1, 3720 BA, Bilthoven, The Netherlands

    Henk C. Walvoort

Authors
  1. Frits R. Mooi
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  2. Han G. J. van der Heide
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  3. Henk C. Walvoort
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  4. Henk Brunings
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  5. Wim H. Jansen
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  6. Piet A. M. Guinee
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Editor information

Editors and Affiliations

  1. Tel Aviv University, Tel Aviv, Israel

    Eliora Z. Ron

  2. The Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Shlomo Rottem

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© 1991 Plenum Press, New York

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Mooi, F.R., van der Heide, H.G.J., Walvoort, H.C., Brunings, H., Jansen, W.H., Guinee, P.A.M. (1991). The Analysis of Bordetella Pertussis Fimbrial Mutants in a Rabbit Model. In: Ron, E.Z., Rottem, S. (eds) Microbial Surface Components and Toxins in Relation to Pathogenesis. Federation of European Microbiological Societies Symposium Series, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8995-8_8

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  • DOI: https://doi.org/10.1007/978-1-4684-8995-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8997-2

  • Online ISBN: 978-1-4684-8995-8

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