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P-Fimbriae: Molecular Aspects of their Structure and their Application as Carriers of Foreign Antigenic Determinants

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Microbial Surface Components and Toxins in Relation to Pathogenesis

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 51))

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Abstract

Urinary tract infections (UTI) are often caused by Escherichia coli. Properties associated with virulence include certain 0- and K-antigens, P-fimbriae, production of hemolysin or colicin and resistance to serum bactericidal activity. Adherence of the bacteria to the uroepithelium is considered to be an important initial event in the pathogenesis of UTI. Adherence and the ability to cause mannose-resis-tant hemagglutination of human erythrocytes are associated in most UTI strains with the presence of P-fimbriae (1). Pfimbriae, or pap-pili, belong to a widely occurring family of fimbriae, filamentous surface components composed of ä thousand protein subunits (for a review see 2). P-fimbriae specifically recognize the α -DGal(1–3) β -DGal moiety of glycolipids, which is also part of the P-blood group antigens (3, 4). Among P-fimbriae a number of different serotypes are discriminated, designated as F7–F14 (5).

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Authors and Affiliations

  1. Department of Molecular Cell Biology, Padualaan 8, 3584CH, Utrecht, The Netherlands

    Irma van Die, Nico Riegman, Joost van Oosterhout, Hans Bergmans, Anneke van der Zee, Hanneke Bes & Wiel Hoekstra

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  1. Irma van Die
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  2. Nico Riegman
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  3. Joost van Oosterhout
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  4. Hans Bergmans
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  5. Anneke van der Zee
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  6. Hanneke Bes
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  7. Wiel Hoekstra
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Editor information

Editors and Affiliations

  1. Tel Aviv University, Tel Aviv, Israel

    Eliora Z. Ron

  2. The Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Shlomo Rottem

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© 1991 Plenum Press, New York

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van Die, I. et al. (1991). P-Fimbriae: Molecular Aspects of their Structure and their Application as Carriers of Foreign Antigenic Determinants. In: Ron, E.Z., Rottem, S. (eds) Microbial Surface Components and Toxins in Relation to Pathogenesis. Federation of European Microbiological Societies Symposium Series, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8995-8_3

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  • DOI: https://doi.org/10.1007/978-1-4684-8995-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8997-2

  • Online ISBN: 978-1-4684-8995-8

  • eBook Packages: Springer Book Archive

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