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Urolithiasis pp 199–208Cite as

Infection-Induced Stones: Status of Clinic Trials with Urostat™ (Acetohydroxamic Acid)

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Abstract

The cause and effect relationship between urinary infection and urinary stones has been since antiquity. Bladder stones that we now perceive as infection induced have been found in Egyptian mummies dating back to 5,000 B.C. Hippocrates recognized that putrifying loin abscesses were commonly associated with renal stones. Marcet (1817) suggested that the evolution of ammonia during putrification alkalinized urine and that such alkalinization was “unavoidably attended by the precipitation of phosphates contained in urine.” Recent experimental and clinical investigations from a number of investigators have validated these historical concepts.

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References

  1. D. P. Griffith, R. R. Bruce, and W. N. Fishbein, in: “Nephrolithiasis,” F. L. Coe, B. M. Brenner, and J. H. Stein, eds., Churchill Livingstone, New York, p. 231 (1980).

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  2. C. Sato, Personal communication.

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  3. J. Donnelly, R. H. Hackler, and R. C. Brents, J. Urol. 108: 558 (1972).

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  4. D. P. Griffith, Kid. Int. 13:372 (1978).

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  5. R. Bruce and D. P. Griffith, in: “Proceedings of the IV International Symposium on Urolithiasis Research,” (in press).

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Author information

Authors and Affiliations

  1. Department of Urology, Baylor College of Medicine, 77030, Houston, Texas, USA

    Donald P. Griffith, Pat Moskowitz & Stuart Feldman

Authors
  1. Donald P. Griffith
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  2. Pat Moskowitz
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  3. Stuart Feldman
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  2. The General Infirmary, Leeds, England

    William G. Robertson

  3. University of Florida, Gainesville, Florida, USA

    Birdwell Finlayson

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© 1981 Springer Science+Business Media New York

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Griffith, D.P., Moskowitz, P., Feldman, S. (1981). Infection-Induced Stones: Status of Clinic Trials with Urostat™ (Acetohydroxamic Acid). In: Smith, L.H., Robertson, W.G., Finlayson, B. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8977-4_33

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  • DOI: https://doi.org/10.1007/978-1-4684-8977-4_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8979-8

  • Online ISBN: 978-1-4684-8977-4

  • eBook Packages: Springer Book Archive

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