Effects of Concanavalin a Pretreatment on Cloned Cytolytic T Cells
Concanavalin A (Con A) and some other lectins have been shown to facilitate lysis of antigenically irrelevant target cells by otherwise specific cytolytic T cells (CTL). The mechanism of the nonspecific recognition in such lectin-facilitated cytolysis is not yet understood; however, simple bridging is apparently not sufficient since some lectins may agglutinate cells and yet not cause target cell lysis (1).
KeywordsTarget Cell Effector Cell Lytic Activity Spontaneous Release Peritoneal Exudate Cell
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