Studies on the Mechanism of Lectin-Dependent T Cell-Mediated Cytolysis: Use of Lens Culinaris Hemagglutinin A to Define the Role of Lectin
Alloimmune cytotoxic T cell populations demonstrate exquisite immunologic specificity, killing only target cells which display alloantigens related to those used for immunization (1,2). It was noted some time ago, however, that in the presence of the plant lectins concanavalin A (Con A) and phythohemagglutinin such specificity is not maintained; rather a variety of target cells, including those syngeneic to the effector cell source, are lysed (3–5).
KeywordsTarget Cell Effector Cell None None Specific Lysis Cell Mitogen
Unable to display preview. Download preview PDF.
- 9.Greeen, W.R., Z.K. Ballas, and C.S. Henney. Studies on the mechanism of lymphocyte-medited cytolysis. XI. The role of lectin in lectin-dependent cell-mediated cytotoxicity. J. Immunol. 121:1566. (1978)Google Scholar
- 10.Parker, W.L., and E. Martz. Lectin-induced nonlethal adhesions between cytolytic T Drmphocytes and antigenically unrecognizable tiimor cells and nonspecific “triggering” of cytolysis. J. Immunol. 125:25. (1980)Google Scholar