Studies on the Mechanism of Lectin-Dependent T Cell-Mediated Cytolysis: Use of Lens Culinaris Hemagglutinin A to Define the Role of Lectin

  • William R. Green
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


Alloimmune cytotoxic T cell populations demonstrate exquisite immunologic specificity, killing only target cells which display alloantigens related to those used for immunization (1,2). It was noted some time ago, however, that in the presence of the plant lectins concanavalin A (Con A) and phythohemagglutinin such specificity is not maintained; rather a variety of target cells, including those syngeneic to the effector cell source, are lysed (3–5).


Target Cell Effector Cell None None Specific Lysis Cell Mitogen 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • William R. Green
    • 1
  1. 1.Program in Basic ImmunologyFred Hutchinson Cancer Research CenterSeattleUSA

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