T Lymphocyte-Mediated Cytolysis — A Comprehensive Theory II. Lytic vs. Nonlytic Interactions of T Lymphocytes

  • William R. Clark
  • Gideon Berke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


In the model for CTL-mediated lysis presented in the preceding paper, we postulated that the binding of CTL to target cells through interaction of an array of MHC-specific T cell receptors with a corresponding array of TC MHC antigens is sufficient, under permissive environmental conditions, to cause TC destruction. However, a variety of other T cell subsets interact with target or partner cells in an MHC-restricted fashion, implying the existence of MHC-specific receptors on these T cells as well. In the mouse, T cells displaying Ly 1 antiens but not Ly 2,3 antigens recognize I region associated (Ia) antigens, and serve as amplifying cells in the differentiation of B cells to plasma cells, and in the activation of pre-CTL to mature, functional CTL. Cells with reduced levels of Ly 1 and high levels of Ly 2,3 serve effector functions as CTL and as suppressors of Ly 1 amplifier cells. Ly 2,3 CTL bear receptors for K/D antigens, whereas Ly 2,3 suppressor cells have receptors for determinants coded for by genes in the I-J subregions. Ly 1 T cells do not normally function as CTL; whether Ly 2,3 suppressor T cells utilize a cytotoxic mechanism in their function is uncertain.


Effector Cell Partner Cell Cell Mediate Cytolysis Lentil Lectin Lytic Signal 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • William R. Clark
    • 1
  • Gideon Berke
    • 2
  1. 1.Department of Biology and the Molecular Biology InstituteUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Cell BiologyWeizmann Institute of ScienceRehovotIsrael

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