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T Lymphocyte-Mediated Cytolysis — A Comprehensive Theory I. The Mechanism of CTL-Mediated Cytolysis

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Mechanisms of Cell-Mediated Cytotoxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 146))

Abstract

The mechanism(s) by which cytotoxic T lymphocyte (CTL) cause lethal and irreversible damage to target cells (TC) has been the subject of considerable research during the past 10–15 years. A number of mechanisms have been proposed, examined, and either have been disproved or have generally not been pursued for lack of convincing experimental evidence in their support. These have included involvement of CTL-associated complement-like components (1,2); direct transfer of molecules, from the CTL to the TC membrane or cytoplasm, that eventually result in death of the target cell (3,4); localized extracellular secretion by the CTL, upon specific contact with the TC, of cytotoxic molecules (5,6); tangential shearing of the TC membrane as a result of CTL-TC conjugation (7); distortion of TC membrane potential (8); and Implication of the CTL membrane as a generalized cytotoxic agent (9). These and other proposed mechanisms have been extensively reviewed (see ref. 10–13). Despite a great deal of imaginative experimentation in pursuit of these various hypotheses, none of them has attracted widespread support as a principle mechanism of CTL-mediated cytolysis.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel

    Gideon Berke

  2. Department of Biology and the Molecular Biology Institute, University of California, 90024, Los Angeles, California, USA

    William R. Clark

Authors
  1. Gideon Berke
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  2. William R. Clark
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Editors and Affiliations

  1. University of California, Los Angeles, California, USA

    William R. Clark

  2. Centre d’lmmunologie, INSERM-CNRS de Marseille-Luminy, Marseille, France

    Pierre Golstein

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© 1982 Plenum Press, New York

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Berke, G., Clark, W.R. (1982). T Lymphocyte-Mediated Cytolysis — A Comprehensive Theory I. The Mechanism of CTL-Mediated Cytolysis. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_4

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  • DOI: https://doi.org/10.1007/978-1-4684-8959-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8961-3

  • Online ISBN: 978-1-4684-8959-0

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