Abstract
Functionally defined cloned T lymphocytes represent a homogeneous population of cells uniquely suited for the analysis of cell surface molecules involved in specific allorecognition, T cell clones expressing either cytolytic or amplifier functions have been derived in this laboratory from unidirectional secondary C57BL/6 anti-DBA/2 mixed lymphocyte culture (MLC) and have been maintained in long term culture (1). One cytolytic clone, designated L3, has been found to express cytolytic activity for the H-2d gene product (2). The L3 cell line has been used in the present study to derive and characterize a monoclonal antibody which reacts specifically with that cell line, and which is capable of inhibiting antigen specific cytolysis in the absence of complement.
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© 1982 Plenum Press, New York
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Lancki, D.W., Lorber, M.I., Loken, M.R., Fitch, F.W. (1982). A Clone Specific Monoclonal Antibody which Inhibits T Cell-Mediated Cytolysis. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_34
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DOI: https://doi.org/10.1007/978-1-4684-8959-0_34
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