The Molecular Basis for Cytolytic T Lymphocyte Function: Analysis with Blocking Monoclonal Antibodies

  • Eric Martz
  • Denise Davignon
  • Konrad Kürzinger
  • Timothy A. Springer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


Cytolytic T lymphocytes (CTL) were identified during the late 1960’s (1,2) and are thought to be important effector cells in immunity to viruses (3) and in allograft rejection (4), Despite considerable effort during the past decade, little has been learned about the biochemical basis for the killing event. Not only do the presumed molecular mediators remain unidentified, but fundamental physiological questions remain unanswered.


Target Cell Mixed Lymphocyte Culture Lymphocyte Membrane Mediate Killing Osmotic Protection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Eric Martz
    • 1
  • Denise Davignon
    • 2
  • Konrad Kürzinger
    • 2
  • Timothy A. Springer
    • 2
  1. 1.The Department of MicrobiologyUniversity of MassachusettsAmherstUSA
  2. 2.The Laboratory of Membrane Immunochemistry, Sidney Farber Cancer InstituteHarvard Medical SchoolBostonUSA

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