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Mechanisms of Tumor Cell Lysis by Natural Killer Cells

  • Chapter
Mechanisms of Cell-Mediated Cytotoxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 146))

Abstract

Immune reactivity against malignant cells is well-documented for a number of lymphoid cell types (1). The foremost features of anti-timor immune effector cells appears to be their capacity to recognize and subsequently kill tumor cells. Nevertheless, the mechanism(s) by which effector cells of the immune response mediate tumor cell lysis is largely unknown. The lack of precise knowledge concerning lytic pathways is evident for well studied immune killer cells, such as cytotoxic T Ijrmphocytes, as well as for effector cells that have only recently received intense experimental scrutiny, such as natural killer (NK) cells.

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Author information

Authors and Affiliations

  1. Cancer Metastasis Research Group, Department of Immunology and Infectious Disease, Pfizer Central Research, 06340, Groton, Connecticut, USA

    Ronald H. Goldfarb

  2. Laboratory of Immunodiagnosis, National Cancer Institute, National Institutes of Health, 20205, Bethesda, Maryland, USA

    Tuomo Timonen & Ronald B. Herberman

Authors
  1. Ronald H. Goldfarb
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  2. Tuomo Timonen
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  3. Ronald B. Herberman
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Editors and Affiliations

  1. University of California, Los Angeles, California, USA

    William R. Clark

  2. Centre d’lmmunologie, INSERM-CNRS de Marseille-Luminy, Marseille, France

    Pierre Golstein

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© 1982 Plenum Press, New York

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Goldfarb, R.H., Timonen, T., Herberman, R.B. (1982). Mechanisms of Tumor Cell Lysis by Natural Killer Cells. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_24

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  • DOI: https://doi.org/10.1007/978-1-4684-8959-0_24

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4684-8959-0

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