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Cell Surface Properties Influencing Target Cell Sensitivity for NK Lysis

  • Chapter
Mechanisms of Cell-Mediated Cytotoxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 146))

Abstract

NK cells are defined by the ability of lymphoid cells from non-immunized or non-primed donors to lyse sensitive targets in short term cytotoxicity assays. Since any known “immunogen” is lacking in this system, this raises obvious difficulties in discussing the nature of the NK target structure. We will here make a brief summary of different cell surface properties which have been suggested to be of importance in conferring NK susceptibility to a target cell, focusing on some recent work from our laboratory.

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Authors and Affiliations

  1. Department of Tumor Biology, Karolinska Institutet, S 104 01, Stockholm, Sweden

    Rolf Kiessling & Alvar Grönberg

Authors
  1. Rolf Kiessling
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  2. Alvar Grönberg
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Editors and Affiliations

  1. University of California, Los Angeles, California, USA

    William R. Clark

  2. Centre d’lmmunologie, INSERM-CNRS de Marseille-Luminy, Marseille, France

    Pierre Golstein

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© 1982 Plenum Press, New York

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Kiessling, R., Grönberg, A. (1982). Cell Surface Properties Influencing Target Cell Sensitivity for NK Lysis. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_21

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  • DOI: https://doi.org/10.1007/978-1-4684-8959-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8961-3

  • Online ISBN: 978-1-4684-8959-0

  • eBook Packages: Springer Book Archive

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