Cell Surface Properties Influencing Target Cell Sensitivity for NK Lysis
NK cells are defined by the ability of lymphoid cells from non-immunized or non-primed donors to lyse sensitive targets in short term cytotoxicity assays. Since any known “immunogen” is lacking in this system, this raises obvious difficulties in discussing the nature of the NK target structure. We will here make a brief summary of different cell surface properties which have been suggested to be of importance in conferring NK susceptibility to a target cell, focusing on some recent work from our laboratory.
KeywordsNatural Killer Natural Killer Cell Sialic Acid Natural Killer Activity Human Natural Killer Cell
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