Skip to main content
SpringerLink
Log in
Book cover

Mechanisms of Cell-Mediated Cytotoxicity pp 337–351Cite as

Overview on NK Cells and Possible Mechanisms for their Cytotoxic Activity

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 146))

Abstract

As evidenced by the strong emphasis of this volume on T cells, there has been a long-standing interest in determining the mechanism of cytolysis by immune T cells. Similarly, much attention has been devoted to the mechanism of cytotoxicity by macrophages, as summarized well here by Key et al (1). During the past few years, natural killer (NK) cells have attracted considerable attention as particularly important elements in natural resistance against tumors and possibly against some microbial infections (2). It therefore is of equal concern to elucidate the mechanism of lysis of target cells by NK cells. A further intriguing question that can be raised, in light of the extensive research on mechanisms of lysis by other effector cells, is whether the mechanism of lysis by NK cells is unique or whether it is similar or even identical to that of one or more of the other cell types. Much of the available evidence on these issues is summarized in the manuscript by Goldfarb et al in this volume (3). Here it seems more appropriate to emphasize the approaches which have been taken to study the mechanism of lysis by NK cells, and to point out current gaps in our knowledge and possible ways to obtain more definitive indications of the critical processes involved in the interaction between NK cells and their target cells.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Key, M.E., et al. See this volume.

    Google Scholar 

  2. Herberman, R.B. (Ed.). In “Natural Cell-Mediated Immunity Against Tumors.” Academic Press, New York, 1321 pp. (1980).

    Google Scholar 

  3. Goldfarb, R.H., Timonen, T., and R.B. Herberman. Mechanisms of tumor cell lysis by natural killer cells. See this volume.

    Google Scholar 

  4. Timonen, T., Ortaldo, J.R., and R.B. Herberman. Characteristics of human large granular Ijmiphocytes and relationship to natural killer and K cells. J. Exp. Med. 153:569 (1981).

    Article  PubMed  CAS  Google Scholar 

  5. Reynolds, C.W., Timonen, T., and R.B. Herberman. Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells. J. Immunol. 127:282 (1981).

    PubMed  CAS  Google Scholar 

  6. Luini, W., Boraschi, D., Alberti, S., Aleotti A., and A. Tagliabue. Morphological characterization of a cell population responsible for natural killer activity. Immunol., in press.

    Google Scholar 

  7. Timonen, T., and E. Saksela. Isolation of human natural killer cells by discontinuous gradient centrifugation. J. Immunol. Methods 36:285 (1980).

    Article  PubMed  CAS  Google Scholar 

  8. Ferrarini, M., Cadoni, A., Franzi, T., Ghigliotti, C., Leprini, A., Zicca, A., and C.E. Grossi. Ultrastructural and cytochem- ical markers of human lymphocytes. In “Thymus, Thymic Hormones and T Lymiphocytes.” Edited by F. Aiuti. Academic Press, New York, p. 39 (1980).

    Google Scholar 

  9. Reiiiherz, E.L., Moretta, L., Roper, M., Breard, J.M., Mingari, M.C., Cooper, M.D., and S.F. Schlossman. Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J. Exp. Med. 151:969 (1980).

    Article  Google Scholar 

  10. Ortaldo J.R., Sharrow, S.O., Timonen, T., and R.B. Herberman. Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. J. Immunol., in press.

    Google Scholar 

  11. Reinherz, E.L., Kung, P.C., Goldstein, G., Levey, R.H., and S.F. Schlossman. Discrete stages of human intrath3miic differentiation: analysis of normal thymocytes and leukemic 13mlpho- blasts of T-cell lineage. Proc. Natl. Acad. Sci. USA 77:1588 (1980).

    Article  PubMed  CAS  Google Scholar 

  12. Glimcher, L., Shen, F.W., and H. Cantor. Identification of a cell-surface antigen selectively expessed on the natural killer cell. J. Exp. Med. 145:1 (1977).

    Article  PubMed  CAS  Google Scholar 

  13. Cantor, H., Kasai, M., Shen, H.W., Ledere, J.C., and L. Gllmcher. Immunogenetlc analysis of natiiral killer activity in the mouse. Immunol. Rev. 44:1 (1979).

    Article  Google Scholar 

  14. Kasai, M., Iwamori, M., Nagai, Y., Okumura, K., and T. Tada. A glycolipid on the surface of mouse natural killer cells. Eur. J. Immunol. 10:174 (1980).

    Google Scholar 

  15. Young, W.W. Jr., Hakomori, S-I., Durdik, J.M., and C.S. Henney. Identification of ganglio-N-tetrasylceramide as a new cell surface marker for murine natural killer (NK) cells. J. Immunol. 124:199 (1980).

    PubMed  CAS  Google Scholar 

  16. Tai, A., and N.L. Warner. Biophysical and serological characterization of murine NK cells. In “Natural Cell-Mediated Immunity Against Tumors.” Edited by R.B. Herberman. Academic Press, New York, p. 241 (1980).

    Google Scholar 

  17. de Landazuri, M.O., Lopez-Botet, M., Timonen, T., Ortaldo, J.R., and R.B. Herberman. Human large granular lymphocytes: Spontaneous and interferon-boosted NK activity against adherent and nonadherent tumor cell lines. J. Immunol. 127:1380 (1981).

    PubMed  Google Scholar 

  18. Stutman, O., Figarella, E.F., Paige, C.J., and E.C. Lattime. Natural cytotoxic (NC) cells against solid tumors in mice: general characteristics and comparison to natural killer (NK) cells. In “Natural Cell-Mediated Immunity Against Tumors.” Edited by R.B. Herberman. Academic Press, New York, p. 187 (1980).

    Google Scholar 

  19. Burton, R.B. Alloantisera selectively reactive with NK cells: characterization and use in defining NK cell classes. In “Natural Cell-Mediated Immunity Against Tumors.” Edited by R.B. Herberman. Academic Press, New York, p. 19 (1980).

    Google Scholar 

  20. Dennert, G. Cloned lines of natural killer cells. Nature 287:47 (1980).

    Article  PubMed  CAS  Google Scholar 

  21. Nabel, G., Bucalo, L.R., Allard, J., Wigzell, H., and H. Cantor. Multiple activities of a cloned cell line mediating natural killer cell function. J. Exp. Med. 153:1582 (1981).

    Article  PubMed  CAS  Google Scholar 

  22. Kedar, E., Herberman, R.B., Gorelik, E., Sredni, B., Bonnard, G.D., and N. Navarro. Antitumor reactivity in vitro and in vivo of mouse and human lymphoid cells cultured with T cell growth factor. “The Potential Role of T Cell Sub populations in Cancer Therapy.” Edited by A. Fefer. Raven Press, New York, in press.

    Google Scholar 

  23. Ortaldo, J.R., Timonen, T.T., Vose, B.M., and J.A. Alvarez. Human natural killer cells as well as T cells maintained in continuous cultures with IL-2. “The Potential Role of TCell Sub populations in Cancer Therapy.” Edited by A. Fefer. Raven Press, New York, in press.

    Google Scholar 

  24. Henney, C. See this volume.

    Google Scholar 

  25. Kiessling, R. See this volume.

    Google Scholar 

  26. Ullberg, M., and M. Jondal. Recycling and target binding capacity of human natural killer cells. J. Exp. Med. 153:615 (1981).

    Google Scholar 

  27. Timonen, T., Ortaldo, J.R., and R.B. Herberman. Analysis by a single cell cytotoxicity assay of natural kill (NK) cell frequencies among human large granular Ijmiphocytes and of the effects of interferon on their activity. Submitted for publication.

    Google Scholar 

  28. Grimm, E., and B. Bonavida. Mechanism of cell-mediated cytotoxicity at the single cell level. I. Estimation of cytotoxic T lymphocyte frequency and relative lytic efficiency. J. Immunol 123:2861 (1979).

    PubMed  CAS  Google Scholar 

  29. Bonavida, B. See this volume.

    Google Scholar 

  30. Reynolds, C.W., Timonen, T., Holden, H.T., Hansen, C.T., and R.B. Herberman. Natural killer (NK) cell activity in the rat. III. Analysis of activity in the athymic (nude) rat. Submitted for publication.

    Google Scholar 

  31. Silva, A., Bonavida, B., and S. Targan. Mode of action of interferon-mediated modulation of natural killer cytotoxic activity: recruitment of pre-NK cells and enhanced kinetics of lysis. J. Immunol. 125:479 (1980).

    PubMed  CAS  Google Scholar 

  32. Kuribayashi, K., Gillis, S., Kern, D.E., and C.S. Henney. Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity. J. Immunol. 126:2321 (1981).

    PubMed  CAS  Google Scholar 

  33. Riccardi, C., Vose, B., and R.B. Herberman. Limiting dilution frequency analysis of mouse NK cells growing in mitogen-free IL-2: regulation by T cells and interferon. _In “Proceedings of the 9th International RES congress, in press.

    Google Scholar 

  34. Saxena, R.K., Adler, W.H., and A.A. Nordin. Modulation of natural cytotoxicity by alloantibodies. IV. A comparative study of the activation of mouse spleen cell cytotoxicity by anti-H2 antisera, interferon, and mitogens. Cell. Immunol. 63:28 (1981).

    Article  PubMed  CAS  Google Scholar 

  35. Brunda, M.J., Herberman, R.B., and H.T. Holden. Interferon- independent activation of murine natural killer cell activity. In “Natural Cell-Mediated Immunity Against Tumors.” Edited by R.B. Herberman. Academic Press, New York, p. 525 (1980).

    Google Scholar 

  36. Brunda, M.J., Herberman, R.B., and H.T. Holden. Antibody- induced augmentation of murine natural killer cell activity. Int. J. Cancer 27:205 (1981).

    Article  PubMed  CAS  Google Scholar 

  37. Blalock, J.E. Inhibition of interferon production by RA (vitamin A acid). Tex. Rep. Biol. Med. 35:69 (1977).

    PubMed  CAS  Google Scholar 

  38. Goldfarb, R.H., and R.B. Herberman. Natural killer cell reactivity: Regulatory interactions among phorbol ester, interferon, cholera toxin, and retinoic acid. J. Immunol. 126:2129 (1981).

    PubMed  CAS  Google Scholar 

  39. Domzig, W., Timonen, T.T., and B.M. Stadler. Human natural killer (NK) cells produce interleukin-2 (IL-2). Proc. Amer. Assoc. Cancer Res. 22:309 (1981).

    Google Scholar 

  40. Roder, J.C., Argov, S., Klein, N.M., Petersson, C., Kiessling, R., Anderson, R., Anderson, K., and M. Hansson. Target- effector interaction in the natural killer cell system. V. Energy requirement, membrane integrity, and the possible involvement of lysosomal enzymes. Immunol. 40:108 (1980).

    Google Scholar 

  41. Stutman, O., Dien, P., Wisim, R, Percoraro, G., and E.G. Lattime. Natural cytotoxic (NG) cells against solid tumors in mice: some target cell characteristics and blocking of cytotoxicity by D-mannose. In “Natural Gell-Mediated Immunity Against Tumors.” Edited by R.B. Herberman. Academic Press, New York, p. 949 (1980).

    Google Scholar 

  42. Ortaldo, J.R., Timonen, T.T., Goldfarb, R.H., and R.B. Herberman. Mechanisms of lysis by natural killer cells: Discrimination between binding and post-binding events. Submitted for publication.

    Google Scholar 

  43. Fischer, H.D., Gonzalez-Noriega, A., Sly, S.W., and D.J. Morre. Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes. J. Biol. Ghem. 255:9608 (1980).

    CAS  Google Scholar 

  44. Wright, S.G., and B. Bonavida. Selective lysis of NK-sensitive target cells by a soluble mediator released from murine spleen cells and human peripheral blood lymphocytes. J. Immunol. 126:1516 (1981).

    PubMed  CAS  Google Scholar 

  45. Roder, J., and A. Duwe. The beige mutation in the mouse selectively impairs natural killer cell function. Nature 278: 451 (1979).

    Article  PubMed  CAS  Google Scholar 

  46. Roder, J.G., Haliotis, T., Klein, M., Korec, S., Jett, J.R., Ortaldo, J., Herberman, R.B., Katz, P., and A.S. Fauci. Anew immunodeficiency disorder in humans involving NK cells. Nature 184:553 (1980).

    Article  Google Scholar 

  47. Henkart, M. and P. Henkart. See this volume.

    Google Scholar 

  48. Goto, T., Maluish, A., Strong, D.M., and R.B. Herberman. Gyclic AMP as a mediator of protaglandin E-induced suppression of human natural killer cell activity. Submitted for publication.

    Google Scholar 

  49. Sulica, A., Gherman, M., Galatiuc, C., Manciulea, M., and R.B. Herberman. Inhibition of human natural killer cell activity by cytophilic immunogloculin G. J. Immunol., in press.

    Google Scholar 

  50. Schmidt, A., Ortaldo, J.R., and R.B. Herberman. Inhibition of human natural killer cell reactivity by exogenous adenosine 5’-triphosphate. Fed. Proc., in press.

    Google Scholar 

  51. Dicker, P., Heppel, L.A., and E. Rozengurt. Gontrol of membrane permeability by external and internal ATP in 3T6 cells grown in serum-free medium. Proc. Natl. Acad. Sci. USA 77: 2103 (1980).

    Article  PubMed  CAS  Google Scholar 

  52. Goldfarb, R.H., Timonen, T., Pick, E., and R.B. Herberman. Evaluation of ability of human large granular lymphocytes and monocytes to display an oxidative burst. Submitted for publication.

    Google Scholar 

  53. Hoffman, T., Hirata, F., Bougnoux, P., Fraser, B.A., Goldfarb, R.H., Herberman, R.B., and J. Axelrod. Phospholipid methyl- ation and phospholipase A2 activation in cytotoxicity by human natural killer cells. Proc Natl. Acad. Sci. 78:3839 (1981).

    Article  PubMed  CAS  Google Scholar 

  54. Hudig, D., Haverty, T., Fucher, G., Redelman, D., and J. Mendelsohn. Inhibition of human natural cytotoxicity by macro- molecular antiproteases. J. Immunol. 126:1569 (1981).

    PubMed  CAS  Google Scholar 

  55. Lavie G., Weiss, H., Pick, A., and E.G. Franklin. The role of surface associated proteases in lymphocyte spontaneous cytolytic activity. Fourth Gongr. Immunol. Abstracts 11.4.30 (1980).

    Google Scholar 

  56. Landazuri, M.O., Silva, A., Alvarez, J., and R.B. Herberman. Evidence that natural cytotoxicity and antibody dependent cellular cytotoxicity are mediated in humans by the same effector cell populations. J. Immunol. 123:252 (1979).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Immunodiagnosis, National Cancer Institute, 20205, Bethesda, MD, USA

    Ronald B. Herberman

Authors
  1. Ronald B. Herberman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of California, Los Angeles, California, USA

    William R. Clark

  2. Centre d’lmmunologie, INSERM-CNRS de Marseille-Luminy, Marseille, France

    Pierre Golstein

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Herberman, R.B. (1982). Overview on NK Cells and Possible Mechanisms for their Cytotoxic Activity. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8959-0_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8961-3

  • Online ISBN: 978-1-4684-8959-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation